The correlation between serum lipid profile and liver synthetic function in cirrhotic patients

Anisa Dwi Fathinasari, Yusra

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Cirrhosis is an end-stage of chronic inflammatory heart disease with fibrosis and micro or macro nodule. Chronic heart disease affects lipid metabolism and disrupts patient’s lipid profile. Cirrhosis can be detected by assessing liver function, one of which is analyzing serum albumin. The aim is to study the lipid profile in patients with cirrhosis and to determine the correlation between serum lipid profile and serum albumin in patients with cirrhosis. Methods: Design of the study is cross sectional, 73 patients with cirrhosis (56 men and 17 women) were obtained from the medical records of the Laboratory Clinical Pathology RSCM. Results: The data were analyzed with Kolmogorov Smirnov test showed a reduction in serum total cholesterol, HDL cholesterol, LDL cholesterol, and triglyceride in cirrhotic patients (mean of 158.07 mg/dL, 39.05 mg/dL, 94.07 mg/dL and median of 92 mg/dL), Pearson test showed a correlation between a reduction of total cholesterol, HDL cholesterol, LDL cholesterol with the reduction of albumin serum in cirrhotic patients (all p <0,05), while there was no correlation between the reduction of triglyceride with the reduction of albumin serum in cirrhotic patiens (p =0,177). Conclusion: This study concludes that there is correlation between the reduction of total cholesterol, HDL cholesterol, LDL cholesterol with the reduction of albumin serum, otherwise there is no correlation between triglyceride with albumin in cirrhotic patients. HDL cholesterol showed the strongest correlation of all.

Original languageEnglish
Pages (from-to)6943-6945
Number of pages3
JournalAdvanced Science Letters
Volume23
Issue number7
DOIs
Publication statusPublished - 1 Jul 2017

Keywords

  • Albumin
  • Cirrhosis
  • HDL
  • LDL
  • Lipid Profile
  • Total Cholesterol
  • Triglyceride

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