TY - JOUR
T1 - The comparison between free thyroxine and thyroid-stimulating hormone levels on melasma severity
T2 - A cross-sectional study
AU - Rahman, Yusnita
AU - Krisanti, Roro Inge Ade
AU - Wisnu, Wismandari
AU - Sitohang, Irma Bernadette S.
N1 - Funding Information:
This research is included in an internationally indexed publication of competitive research grants for Universitas Indonesia student final project (PITTA) B year 2019 under letter number PENG-1/UN2.R3.1/PPM.00/2019.
Publisher Copyright:
© 2021 Yusnita Rahman, Roro Inge Ade Krisanti, Wismandari Wisnu, Irma Bernadette S. Sitohang.
PY - 2021
Y1 - 2021
N2 - BACKGROUND: Melasma has been suspected to be linked with levels of thyroid hormone. There is no study that explains the association between thyroid hormone levels with melasma severity. AIM: This study aims to find the discrepancies in the levels of thyroid hormone in varying severity of melasma using two different measurement techniques. METHODS: Subjects were chosen consecutively from the dermatology clinic at RSUPN Dr. Cipto Mangunkusumo hospital. Forty-eight patients participated in this study were categorized into mild melasma and moderate-severe melasma based on modified melasma area and severity index (mMASI) and Janus II measurement. RESULTS: Statistically, mMASI measurement showed no significant association between varying melasma severity with levels of thyroid stimulating hormone and free T4 (FT4), p = 0.375 and p = 0.208, respectively. The Janus II examination using polarized light modality has a weak positive correlation with the serum FT4 level (r = 0.3; p = 0.039). Weak correlation was also found between the two measurement strategies, Janus II and mMASI (r = 0.314; p = 0.03). CONCLUSION: There are no significant differences observed in levels of thyroid hormone between subjects with varying degrees of melasma severity.
AB - BACKGROUND: Melasma has been suspected to be linked with levels of thyroid hormone. There is no study that explains the association between thyroid hormone levels with melasma severity. AIM: This study aims to find the discrepancies in the levels of thyroid hormone in varying severity of melasma using two different measurement techniques. METHODS: Subjects were chosen consecutively from the dermatology clinic at RSUPN Dr. Cipto Mangunkusumo hospital. Forty-eight patients participated in this study were categorized into mild melasma and moderate-severe melasma based on modified melasma area and severity index (mMASI) and Janus II measurement. RESULTS: Statistically, mMASI measurement showed no significant association between varying melasma severity with levels of thyroid stimulating hormone and free T4 (FT4), p = 0.375 and p = 0.208, respectively. The Janus II examination using polarized light modality has a weak positive correlation with the serum FT4 level (r = 0.3; p = 0.039). Weak correlation was also found between the two measurement strategies, Janus II and mMASI (r = 0.314; p = 0.03). CONCLUSION: There are no significant differences observed in levels of thyroid hormone between subjects with varying degrees of melasma severity.
KW - Free T4
KW - Janus II facial analysis system
KW - Melasma
KW - Modified melasma area and severity index
KW - Thyroid-stimulating hormone
UR - http://www.scopus.com/inward/record.url?scp=85108964003&partnerID=8YFLogxK
U2 - 10.3889/oamjms.2021.5952
DO - 10.3889/oamjms.2021.5952
M3 - Article
AN - SCOPUS:85108964003
SN - 1857-5749
VL - 9
SP - 426
EP - 431
JO - Open Access Macedonian Journal of Medical Sciences
JF - Open Access Macedonian Journal of Medical Sciences
ER -