The association of plasminogen activator inhibitor-1 level with ischemic stroke (preliminary study)

Yenny Surjawan, Rahajuningsih D. Setiabudy, Marzuki Suryaatmadja, Teguh A.S. Ranakusuma

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Aim Recently, increased plasminogen activator inhibitor-1 (PAI-1) has been known a risk factor for ischemic heart disease. However, the association of increased PAI-1 level with ischemic stroke remains unclear. The aim of this study was to analyze the association of PAI-1 level with ischemic stroke. Methods By case control design we involved 38 ischemic stroke and 38 risky-matched control subjects who fulfilled the criteria. The PAI-1 level was determined by ELISA method using Asserachrom PAI-1 from Stago. Results High PAI-1 level was found more frequent in ischemic stroke subjects than in control subjects (21.1% vs. 7.9 % with OR 3.1; 95 % CI 0.757 – 12.790). The analysis of all studied subjects showed that there was a weak negative correlation between PAI-1 level and age (r = -0.4; P = 0.000). High PAI-1 level was found more frequent in younger (40 – 58 years old) than in the older subjects (60 – 84 years old) (20% vs. 9.8 %) (p=0.004). Conclusion The result of this preliminary study suggested an association between PAI-1 level and ischemic stroke in younger age. Further study with larger subjects is recommended to confirm this association.

Original languageEnglish
Pages (from-to)158-163
Number of pages6
JournalMedical Journal of Indonesia
Volume19
Issue number3
DOIs
Publication statusPublished - 1 Aug 2010

Keywords

  • Ischemic stroke
  • Plasminogen activator inhibitor-1
  • Stroke risk factors

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