TY - JOUR
T1 - The association between therapeutic plasma exchange and the risk of mortality among patients critically ill with COVID-19
T2 - A meta-analysis.
AU - Wardhani, Shinta Oktya
AU - Fajar, Jonny Karunia
AU - Soegiarto, Gatot
AU - Wulandari, Laksmi
AU - Maliga, Helnida Anggun
AU - Ilmawan, Muhammad
AU - Merysa, Risna
AU - Simamora, Arlentina Bentivolia
AU - Aini, Qurrata
AU - Noviantari, Komang
AU - Lestari, Ayu Widya
AU - Harnila, Maria Yoheni
AU - Syafi'i, Imam
AU - Djianzonie, Jane Andrea Christiano
AU - Siagian, Nenci
AU - Nining, Sri
AU - Hanim, Risyda Zakiyah
AU - Wahyuni, Wahyuni
AU - Aulia, Fitri
AU - Juliansyah, Juliansyah
AU - Mahmud, Reflin
AU - Tamara, Fredo
AU - Mahendra, Aditya Indra
AU - Wowor, Amanda Cininta
AU - Baladraf, Fikri
AU - Hadinata, Ponda Hernest
AU - Ikkeputri, Adhityari
AU - Nadya, Hana
AU - Kartini, Dessy Aprilia
AU - Husnah, Milda
AU - Nainu, Firzan
AU - Harapan, Harapan
N1 - Funding Information:
We thank Lembaga Pengelola Dana Pendidikan (LPDP) Republic of Indonesia for supporting this project.
Publisher Copyright:
© 2021 Wardhani SO et al.
PY - 2021
Y1 - 2021
N2 - Background: Cytokine storm has been widely known to contribute to the development of the critical condition in patients with coronavirus disease 2019 (COVID-19), and studies had been conducted to assess the potential aspect of cytokine storm elimination by performing therapeutic plasma exchange (TPE). However, contradictory findings were observed. The objective of this study was to assess the association between TPE and the reduction of mortality of critically ill COVID-19 patients. Methods: A meta-analysis was conducted by collecting data from PubMed, Scopus, and Web of Science. Data on the mortality rate of critically ill COVID-19 patients treated with TPE plus standard of care and that of patients treated with standard of care alone were analyzed using a Z test. Results: We included a total of four papers assessing the association between TPE and the risk of mortality among critically ill COVID-19 patients. Our findings suggested that critically ill COVID-19 patients treated with TPE had lower risk of mortality compared to those without TPE treatment. Conclusion: Our study has identified the potential benefits of TPE in reducing the risk of mortality among critically ill COVID-19 patients.
AB - Background: Cytokine storm has been widely known to contribute to the development of the critical condition in patients with coronavirus disease 2019 (COVID-19), and studies had been conducted to assess the potential aspect of cytokine storm elimination by performing therapeutic plasma exchange (TPE). However, contradictory findings were observed. The objective of this study was to assess the association between TPE and the reduction of mortality of critically ill COVID-19 patients. Methods: A meta-analysis was conducted by collecting data from PubMed, Scopus, and Web of Science. Data on the mortality rate of critically ill COVID-19 patients treated with TPE plus standard of care and that of patients treated with standard of care alone were analyzed using a Z test. Results: We included a total of four papers assessing the association between TPE and the risk of mortality among critically ill COVID-19 patients. Our findings suggested that critically ill COVID-19 patients treated with TPE had lower risk of mortality compared to those without TPE treatment. Conclusion: Our study has identified the potential benefits of TPE in reducing the risk of mortality among critically ill COVID-19 patients.
KW - COVID-19therapeutic plasma exchangecytokine stormtreatment
UR - http://www.scopus.com/inward/record.url?scp=85122857082&partnerID=8YFLogxK
U2 - 10.12688/f1000research.74972.1
DO - 10.12688/f1000research.74972.1
M3 - Review article
C2 - 35083038
AN - SCOPUS:85122857082
SN - 2046-1402
VL - 10
JO - F1000Research
JF - F1000Research
M1 - 1280
ER -