THD-Tricluster method on gene expression data of multiple sclerosis patients receiving interferon-beta therapy

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Abstract

THD-Tricluster method is a triclustering analysis with a biclustering-based approach. The THD-Tricluster method uses the Shifting-and-Scaling Similarity (SSSim) value to form a bicluster first and shows it by forming a tricluster. The SSSim value uses Shifting-and-Scaling Correlation to use an interface with shifting and scaling patterns as well as intertemporal coherence and compares it with the threshold value. THD-Tricluster method was performed on treatment response data to interferon-beta therapy in multiple sclerosis patients. The optimal scenario is a scenario with a coverage value scenario that uses the highest threshold value. In this scenario, there are two types of tricluster, namely the tricluster which has a collection of genes in responsive patients and patients who are not responsive to therapy. The differences collection of genes in both tricluster can be used by medical professionals in the development of interferon-beta therapy treatments to create a therapy response on multiple sclerosis disease.

Original languageEnglish
Title of host publicationProceedings of the 6th International Symposium on Current Progress in Mathematics and Sciences 2020, ISCPMS 2020
EditorsTribidasari A. Ivandini, David G. Churchill, Youngil Lee, Yatimah Binti Alias, Chris Margules
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735441132
DOIs
Publication statusPublished - 23 Jul 2021
Event6th International Symposium on Current Progress in Mathematics and Sciences 2020, ISCPMS 2020 - Depok, Indonesia
Duration: 27 Oct 202028 Oct 2020

Publication series

NameAIP Conference Proceedings
Volume2374
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference6th International Symposium on Current Progress in Mathematics and Sciences 2020, ISCPMS 2020
Country/TerritoryIndonesia
CityDepok
Period27/10/2028/10/20

Keywords

  • Biclustering-based approach
  • coverage
  • shifting-and-scaling correlation
  • threshold
  • triclustering

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