Terpenoid from Indonesian temu mangga (Curcuma mangga, Val) rhizomes and review of its anticancer towards MCF-7 breast cells

Alicia N.A. Ganur, Dyah U.C. Rahayu, Hanhan Dianhar, Ichsan Irwanto, Purwantiningsih Sugita

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Belonging to Zingiberaceae family, temu mangga (Curcuma manga Val) are could be easily found in South East Asian countries including Indonesia. Traditionally, temu mangga have been used to cure many diseases. This research focused to isolate terpenoid compounds from C. mangga Val. rhizomes cultivated in Trop BRC garden LPPM-IPB, West Java, Indonesia in January 2019. C. mangga rhizomes were macerated in acetone then followed by increasing polarity partitions with n-hexane, EtOAc, and methanol, subsequently. One isolated fraction was obtained from various chromatography techniques of n-Hexane fraction. The isolated fraction then was subjected by LCMS/MS. According to LC-MS/MS data, the isolated fraction was a mixture consisted of terpenoids derivatives, i.e. zedoarondiol (1), curcumenol (2), curcumenone (3), and 13-hydroxygermacrone (4). Based on literature studies, terpenoids from Indonesian Curcuma Genus could be developed as an anticancer agent to inhibit MCF-7 breast cells' growth.

Original languageEnglish
Title of host publication4th International Seminar on Chemistry
EditorsYuly Kusumawati, Adi Setyo Purnomo
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735441002
DOIs
Publication statusPublished - 24 Jun 2021
Event4th International Seminar on Chemistry, ISoC 2021 - Surabaya, Indonesia
Duration: 7 Oct 20208 Oct 2020

Publication series

NameAIP Conference Proceedings
Volume2349
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference4th International Seminar on Chemistry, ISoC 2021
Country/TerritoryIndonesia
CitySurabaya
Period7/10/208/10/20

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