Terpenoid from Indonesian temu mangga (Curcuma mangga, Val) rhizomes and review of its anticancer towards MCF-7 breast cells

Alicia N.A. Ganur; Dyah U.C. Rahayu; Hanhan Dianhar; Ichsan Irwanto; Purwantiningsih Sugita

doi:10.1063/5.0051538

Terpenoid from Indonesian temu mangga (Curcuma mangga, Val) rhizomes and review of its anticancer towards MCF-7 breast cells

Alicia N.A. Ganur, Dyah U.C. Rahayu, Hanhan Dianhar, Ichsan Irwanto, Purwantiningsih Sugita

Department of Chemistry

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

2 Citations (Scopus)

Abstract

Belonging to Zingiberaceae family, temu mangga (Curcuma manga Val) are could be easily found in South East Asian countries including Indonesia. Traditionally, temu mangga have been used to cure many diseases. This research focused to isolate terpenoid compounds from C. mangga Val. rhizomes cultivated in Trop BRC garden LPPM-IPB, West Java, Indonesia in January 2019. C. mangga rhizomes were macerated in acetone then followed by increasing polarity partitions with n-hexane, EtOAc, and methanol, subsequently. One isolated fraction was obtained from various chromatography techniques of n-Hexane fraction. The isolated fraction then was subjected by LCMS/MS. According to LC-MS/MS data, the isolated fraction was a mixture consisted of terpenoids derivatives, i.e. zedoarondiol (1), curcumenol (2), curcumenone (3), and 13-hydroxygermacrone (4). Based on literature studies, terpenoids from Indonesian Curcuma Genus could be developed as an anticancer agent to inhibit MCF-7 breast cells' growth.

Original language	English
Title of host publication	4th International Seminar on Chemistry
Editors	Yuly Kusumawati, Adi Setyo Purnomo
Publisher	American Institute of Physics Inc.
ISBN (Electronic)	9780735441002
DOIs	https://doi.org/10.1063/5.0051538
Publication status	Published - 24 Jun 2021
Event	4th International Seminar on Chemistry, ISoC 2021 - Surabaya, Indonesia Duration: 7 Oct 2020 → 8 Oct 2020

Publication series

Name	AIP Conference Proceedings
Volume	2349
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Conference

Conference	4th International Seminar on Chemistry, ISoC 2021
Country/Territory	Indonesia
City	Surabaya
Period	7/10/20 → 8/10/20

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10.1063/5.0051538

Cite this

Ganur, A. N. A., Rahayu, D. U. C., Dianhar, H., Irwanto, I., & Sugita, P. (2021). Terpenoid from Indonesian temu mangga (Curcuma mangga, Val) rhizomes and review of its anticancer towards MCF-7 breast cells. In Y. Kusumawati, & A. S. Purnomo (Eds.), 4th International Seminar on Chemistry Article 020044 (AIP Conference Proceedings; Vol. 2349). American Institute of Physics Inc.. https://doi.org/10.1063/5.0051538

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title = "Terpenoid from Indonesian temu mangga (Curcuma mangga, Val) rhizomes and review of its anticancer towards MCF-7 breast cells",

abstract = "Belonging to Zingiberaceae family, temu mangga (Curcuma manga Val) are could be easily found in South East Asian countries including Indonesia. Traditionally, temu mangga have been used to cure many diseases. This research focused to isolate terpenoid compounds from C. mangga Val. rhizomes cultivated in Trop BRC garden LPPM-IPB, West Java, Indonesia in January 2019. C. mangga rhizomes were macerated in acetone then followed by increasing polarity partitions with n-hexane, EtOAc, and methanol, subsequently. One isolated fraction was obtained from various chromatography techniques of n-Hexane fraction. The isolated fraction then was subjected by LCMS/MS. According to LC-MS/MS data, the isolated fraction was a mixture consisted of terpenoids derivatives, i.e. zedoarondiol (1), curcumenol (2), curcumenone (3), and 13-hydroxygermacrone (4). Based on literature studies, terpenoids from Indonesian Curcuma Genus could be developed as an anticancer agent to inhibit MCF-7 breast cells' growth.",

author = "Ganur, {Alicia N.A.} and Rahayu, {Dyah U.C.} and Hanhan Dianhar and Ichsan Irwanto and Purwantiningsih Sugita",

note = "Publisher Copyright: {\textcopyright} 2021 Author(s).; 4th International Seminar on Chemistry, ISoC 2021 ; Conference date: 07-10-2020 Through 08-10-2020",

year = "2021",

month = jun,

day = "24",

doi = "10.1063/5.0051538",

language = "English",

series = "AIP Conference Proceedings",

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Ganur, ANA, Rahayu, DUC, Dianhar, H, Irwanto, I & Sugita, P 2021, Terpenoid from Indonesian temu mangga (Curcuma mangga, Val) rhizomes and review of its anticancer towards MCF-7 breast cells. in Y Kusumawati & AS Purnomo (eds), 4th International Seminar on Chemistry., 020044, AIP Conference Proceedings, vol. 2349, American Institute of Physics Inc., 4th International Seminar on Chemistry, ISoC 2021, Surabaya, Indonesia, 7/10/20. https://doi.org/10.1063/5.0051538

Terpenoid from Indonesian temu mangga (Curcuma mangga, Val) rhizomes and review of its anticancer towards MCF-7 breast cells. / Ganur, Alicia N.A.; Rahayu, Dyah U.C.; Dianhar, Hanhan et al.
4th International Seminar on Chemistry. ed. / Yuly Kusumawati; Adi Setyo Purnomo. American Institute of Physics Inc., 2021. 020044 (AIP Conference Proceedings; Vol. 2349).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Terpenoid from Indonesian temu mangga (Curcuma mangga, Val) rhizomes and review of its anticancer towards MCF-7 breast cells

AU - Ganur, Alicia N.A.

AU - Rahayu, Dyah U.C.

AU - Dianhar, Hanhan

AU - Irwanto, Ichsan

AU - Sugita, Purwantiningsih

PY - 2021/6/24

Y1 - 2021/6/24

N2 - Belonging to Zingiberaceae family, temu mangga (Curcuma manga Val) are could be easily found in South East Asian countries including Indonesia. Traditionally, temu mangga have been used to cure many diseases. This research focused to isolate terpenoid compounds from C. mangga Val. rhizomes cultivated in Trop BRC garden LPPM-IPB, West Java, Indonesia in January 2019. C. mangga rhizomes were macerated in acetone then followed by increasing polarity partitions with n-hexane, EtOAc, and methanol, subsequently. One isolated fraction was obtained from various chromatography techniques of n-Hexane fraction. The isolated fraction then was subjected by LCMS/MS. According to LC-MS/MS data, the isolated fraction was a mixture consisted of terpenoids derivatives, i.e. zedoarondiol (1), curcumenol (2), curcumenone (3), and 13-hydroxygermacrone (4). Based on literature studies, terpenoids from Indonesian Curcuma Genus could be developed as an anticancer agent to inhibit MCF-7 breast cells' growth.

AB - Belonging to Zingiberaceae family, temu mangga (Curcuma manga Val) are could be easily found in South East Asian countries including Indonesia. Traditionally, temu mangga have been used to cure many diseases. This research focused to isolate terpenoid compounds from C. mangga Val. rhizomes cultivated in Trop BRC garden LPPM-IPB, West Java, Indonesia in January 2019. C. mangga rhizomes were macerated in acetone then followed by increasing polarity partitions with n-hexane, EtOAc, and methanol, subsequently. One isolated fraction was obtained from various chromatography techniques of n-Hexane fraction. The isolated fraction then was subjected by LCMS/MS. According to LC-MS/MS data, the isolated fraction was a mixture consisted of terpenoids derivatives, i.e. zedoarondiol (1), curcumenol (2), curcumenone (3), and 13-hydroxygermacrone (4). Based on literature studies, terpenoids from Indonesian Curcuma Genus could be developed as an anticancer agent to inhibit MCF-7 breast cells' growth.

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U2 - 10.1063/5.0051538

DO - 10.1063/5.0051538

M3 - Conference contribution

AN - SCOPUS:85125153348

T3 - AIP Conference Proceedings

BT - 4th International Seminar on Chemistry

A2 - Kusumawati, Yuly

A2 - Purnomo, Adi Setyo

PB - American Institute of Physics Inc.

T2 - 4th International Seminar on Chemistry, ISoC 2021

Y2 - 7 October 2020 through 8 October 2020

ER -

Terpenoid from Indonesian temu mangga (Curcuma mangga, Val) rhizomes and review of its anticancer towards MCF-7 breast cells

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