Micropulse Trans-Scleral Cyclophotocoagulation (MP-TSCPC) Laser omits a fractioned continuous wave diode laser that targets the ciliary body, which produces aqueous humor, in order to reduce the Intraocular Pressure (IOP). It is commonly used for refractory glaucoma that is difficult to treat using medication or surgery. This case series assessed the effect of MP-TSCPC in five glaucomatous eye from patients in Cipto Mangunkusumo Hospital in March-May 2017. An inclusion criteria in this case includes glaucomatous eyes with IOP more than 21 mmHg that is non-responsive to glaucoma medication or surgery. MP-TSCPC was considered successful if the IOP reduced more than 30% from the initial IOP. There were two absolute Primary Closed Angle Glaucoma (PCAG), two moderate and severe Primary Open Angle Glaucoma (POAG) and one secondary glaucoma case. Initial mean IOP was 36 ± 107 mmHg, in which one month after MPTSCPC the mean IOP reduced to 19,6 ± 5,1 mmHg. All of the patients in this case series had reduced IOP more than 30% with no loss of visual acuity nor phthisis bulbi. This method was successful in reducing IOP in glaucomatous eye without any side effect, only post-operative pain was complained by the patients after the procedure, in which it was relieved using analgesic medication.