Hypnotherapy has not been widely known and developed as a nursing therapy in Indonesia. The research was aimed to identify the effect of hypnosis in reducing the pain sensation of orthopedic post-operative patients. This quasy-experimental study involved 32 respondents, 16 respondents for each control and intervention group. The pain was measured by numeric pain intensity scale of 0 to 5. The hypnotherapy procedure was conducted using a cassette-recorder. The data were undertaken directly by the researcher at two hospitals. Independent t-test showed that there was a significant average deviation of the pain sensation level in the pre and post therapy from both groups (P = 0.020, = 0.05). However, the average deviation of pain sensation level of the intervention group was greater than the control group. The same result was obtained with paired t-test sample. There was a significant average deviation of pain sensation levels in the pre and post therapy for both groups (p = 0.000, = 0.05). The combination therapy between analgesic and hypnotherapy was more effective in reducing the level of orthopedic postoperative pain sensation than the single therapy.