TY - JOUR
T1 - Temoporfin mediated photodynamic therapy in patients with local persistent and recurrent nasopharyngeal carcinoma after curative radiotherapy
T2 - A feasibility study
AU - Nyst, H. J.
AU - Wildeman, M. A.
AU - Indrasari, S. R.
AU - Karakullukcu, B.
AU - van Veen, R. L.P.
AU - Adham, M.
AU - Stewart, F. A.
AU - Levendag, P. C.
AU - Sterenborg, H. J.C.M.
AU - Tan, I. B.
N1 - Funding Information:
The authors would like to thank Winrich Rauschning for helping with the study design. This project was supported by Biolitec Pharma Ltd., Dublin, Ireland.
PY - 2012/9
Y1 - 2012/9
N2 - Background: The treatment of persistent and recurrent nasopharyngeal carcinoma (NPC) remains a challenge, especially in Indonesia. We investigated the safety and efficacy of temoporfin mediated photodynamic therapy (PDT) for patients with local persistent and recurrent NPC. Material and methods: Twenty-two patients with persistent and recurrent NPC (maximum tumor depth <10mm) underwent PDT under local anesthesia with use of a nasopharyngeal light applicator. Three different drug doses and light intervals have been administered: treatment arm A: 0.15mg/kg Foscan®; 96h drug-light interval; B: drug dose of 0.10mg/, 48h drug-light interval; C: drug dose of 0.075mg/kg, 24h drug-light interval. Toxicity was measured by using the CTCAE 3.1 scale. Results: Arm A consisted of eight patients, arms B and C consisted of seven patients. The treatment procedure was well tolerable under local anesthesia. The most common grade III toxicities for all groups is headache (n=7; 33%). No grade IV toxicity was seen. One patient died 2 days after treatment due to a misdiagnosed pneumonia. In 17 of the 22 patients a biopsy was performed after 40 weeks and showed no tumor in all biopsies. Arm A seems, in addition to comparable toxicity, clinically more effective than arms B and C. Conclusion: The present study demonstrated that temoporfin mediated photodynamic therapy is a relatively simple technique that can be utilized to treat residual or recurrent nasopharyngeal cancer, restricted locally to the nasopharynx.
AB - Background: The treatment of persistent and recurrent nasopharyngeal carcinoma (NPC) remains a challenge, especially in Indonesia. We investigated the safety and efficacy of temoporfin mediated photodynamic therapy (PDT) for patients with local persistent and recurrent NPC. Material and methods: Twenty-two patients with persistent and recurrent NPC (maximum tumor depth <10mm) underwent PDT under local anesthesia with use of a nasopharyngeal light applicator. Three different drug doses and light intervals have been administered: treatment arm A: 0.15mg/kg Foscan®; 96h drug-light interval; B: drug dose of 0.10mg/, 48h drug-light interval; C: drug dose of 0.075mg/kg, 24h drug-light interval. Toxicity was measured by using the CTCAE 3.1 scale. Results: Arm A consisted of eight patients, arms B and C consisted of seven patients. The treatment procedure was well tolerable under local anesthesia. The most common grade III toxicities for all groups is headache (n=7; 33%). No grade IV toxicity was seen. One patient died 2 days after treatment due to a misdiagnosed pneumonia. In 17 of the 22 patients a biopsy was performed after 40 weeks and showed no tumor in all biopsies. Arm A seems, in addition to comparable toxicity, clinically more effective than arms B and C. Conclusion: The present study demonstrated that temoporfin mediated photodynamic therapy is a relatively simple technique that can be utilized to treat residual or recurrent nasopharyngeal cancer, restricted locally to the nasopharynx.
KW - Naspoharyngeal carcinoma
KW - Persistent and recurrent nasopharyngeal carcinoma
KW - Photodynamic therapy
UR - http://www.scopus.com/inward/record.url?scp=84865958158&partnerID=8YFLogxK
U2 - 10.1016/j.pdpdt.2012.07.002
DO - 10.1016/j.pdpdt.2012.07.002
M3 - Article
C2 - 22959807
AN - SCOPUS:84865958158
SN - 1572-1000
VL - 9
SP - 274
EP - 281
JO - Photodiagnosis and Photodynamic Therapy
JF - Photodiagnosis and Photodynamic Therapy
IS - 3
ER -