T Cell Responsiveness Correlates Differentially with Antibody Isotype Levels in Clinical and Asymptomatic Filariasis

Maria Yazdanbakhsh, William A. Paxton, Yvonne C.M. Kruize, Erliyani Sartono, Agnes Kurniawan, Angelique Wout van het, Murray E. Selkirk, Felix Partono, Rick M. Maizels, Maria Yazdanbakhsh, William A. Paxton, Yvonne C.M. Kruize, Erliyani Sartono, Agnes Kurniawan, Angelique Wout van het, Murray E. Selkirk, Felix Partono, Rick M. Maizels, Maria Yazdanbakhsh, William A. PaxtonYvonne C.M. Kruize, Erliyani Sartono, Agnes Kurniawan, Angelique Wout van het, Murray E. Selkirk, Felix Partono, Rick M. Maizels

Research output: Contribution to journalArticlepeer-review

86 Citations (Scopus)

Abstract

To establish the relationships among T and B cell responses, active infection, and clinical manifestations in lymphatic filariasis, filarial-specific lymphocyte proliferation, IgG antibody isotypes, and IgE levels were determined in an exposed population: 31 asymptomatic amicrofilaremics, 43 microfilaremics, 12 symptomatic amicrofilaremics, and 52 elephantiasis patients. Lymphocyte proliferation was higher in elephantiasis patients and asymptomatic amicrofilaremics than in microfilaremics (P <.004). A proportion of asymptomatic amicrofilaremics (32%), elephantiasis patients (37%), and symptomatic amicrofilaremics (58%) showed antigen-specific lymphocyte unresponsiveness, and lymphocyte proliferation to filarial antigens correlated negatively with specific IgG41eveis (ρ = -0.315, P <.001). As elevated specific IgG4 is an indicator of active infection, it is argued that active infection may result in lymphocyte hypo responsiveness irrespective of clinical category. Ofthose with elevated specific IgE levels and high T cell proliferative responses, 70% had elephantiasis, suggesting these factors have a role in pathology. However, the existence of a proportion of elephantiasis patients with low anti-filarial IgE and T cell unresponsiveness to filarial antigens suggests that elephantiasis can be caused by distinct processes.

Original languageEnglish
Pages (from-to)925-931
Number of pages7
JournalJournal of Infectious Diseases
Volume167
Issue number4
DOIs
Publication statusPublished - 1 Jan 1993

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