T-cell activation and the balance of antibody isotypes in human lymphatic filariasis

R. M. Maizels; E. Sartono; Agnes Kurniawan; F. Partono; M. E. Selkirk; M. Yazdanbakhsh

doi:10.1016/0169-4758(95)80116-2

T-cell activation and the balance of antibody isotypes in human lymphatic filariasis

R. M. Maizels, E. Sartono, Agnes Kurniawan, F. Partono, M. E. Selkirk, M. Yazdanbakhsh

Department of Parasitology Pre Clinic

Research output: Contribution to journal › Review article › peer-review

143 Citations (Scopus)

Abstract

Human filarial infection presents a spectrum of clinical states with two major poles: asymptomatic microfilaraemia and amicrofilaraemic chronic disease. Microfilaremia is associated with a Th1-type tolerance, and maximal IgG4 antibodies, while elephantiasis patients react across a broad range of immune parameters. In this review, Rick Maizels and his colleagues discuss recent advances in the immunology of human filariasis and present a summary of their latest studies in an endemic area of Indonesia.

Original language	English
Pages (from-to)	50-56
Number of pages	7
Journal	Parasitology Today
Volume	11
Issue number	2
DOIs	https://doi.org/10.1016/0169-4758(95)80116-2
Publication status	Published - Feb 1995

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10.1016/0169-4758(95)80116-2

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abstract = "Human filarial infection presents a spectrum of clinical states with two major poles: asymptomatic microfilaraemia and amicrofilaraemic chronic disease. Microfilaremia is associated with a Th1-type tolerance, and maximal IgG4 antibodies, while elephantiasis patients react across a broad range of immune parameters. In this review, Rick Maizels and his colleagues discuss recent advances in the immunology of human filariasis and present a summary of their latest studies in an endemic area of Indonesia.",

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AU - Maizels, R. M.

AU - Sartono, E.

AU - Kurniawan, Agnes

AU - Partono, F.

AU - Selkirk, M. E.

AU - Yazdanbakhsh, M.

PY - 1995/2

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N2 - Human filarial infection presents a spectrum of clinical states with two major poles: asymptomatic microfilaraemia and amicrofilaraemic chronic disease. Microfilaremia is associated with a Th1-type tolerance, and maximal IgG4 antibodies, while elephantiasis patients react across a broad range of immune parameters. In this review, Rick Maizels and his colleagues discuss recent advances in the immunology of human filariasis and present a summary of their latest studies in an endemic area of Indonesia.

AB - Human filarial infection presents a spectrum of clinical states with two major poles: asymptomatic microfilaraemia and amicrofilaraemic chronic disease. Microfilaremia is associated with a Th1-type tolerance, and maximal IgG4 antibodies, while elephantiasis patients react across a broad range of immune parameters. In this review, Rick Maizels and his colleagues discuss recent advances in the immunology of human filariasis and present a summary of their latest studies in an endemic area of Indonesia.

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U2 - 10.1016/0169-4758(95)80116-2

DO - 10.1016/0169-4758(95)80116-2

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JO - Parasitology Today

JF - Parasitology Today

IS - 2

ER -

T-cell activation and the balance of antibody isotypes in human lymphatic filariasis

Abstract

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