T-cell activation and the balance of antibody isotypes in human lymphatic filariasis

R. M. Maizels, E. Sartono, Agnes Kurniawan, F. Partono, M. E. Selkirk, M. Yazdanbakhsh

Research output: Contribution to journalReview articlepeer-review

138 Citations (Scopus)

Abstract

Human filarial infection presents a spectrum of clinical states with two major poles: asymptomatic microfilaraemia and amicrofilaraemic chronic disease. Microfilaremia is associated with a Th1-type tolerance, and maximal IgG4 antibodies, while elephantiasis patients react across a broad range of immune parameters. In this review, Rick Maizels and his colleagues discuss recent advances in the immunology of human filariasis and present a summary of their latest studies in an endemic area of Indonesia.

Original languageEnglish
Pages (from-to)50-56
Number of pages7
JournalParasitology Today
Volume11
Issue number2
DOIs
Publication statusPublished - 1 Jan 1995

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