Systemic ventricle morphology impact on ten-year survival after Fontan surgery

Mira Fauziah, Oktavia Lilyasari, Lies Dina Liastuti, Budi Rahmat

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: The Fontan procedure has been applied in many patients with single-ventricle physiology, with quite low mortality rates all over the world, and a 8.6%–9.1% rate in Indonesia. Structural and characteristic differences in the morphologically left and right ventricles influence the role of the systemic ventricle in the functionally univentricular heart and impact on postoperative outcomes. Mid- and long-term survival based on systemic ventricle morphology remains controversial. This study aimed to investigate the impact of systemic ventricle morphology on ten-year survival after the Fontan procedure. Methods: The 162 patients who underwent a Fontan operation at our institution between 2008 and February 2018 and survived to discharge were reviewed and followed up until March 2018. Data were extracted from the registry and pediatric surgical conferences, medical records, surgery reports, echocardiography and catheterization reports, and follow-up to the end of the study period. Median follow-up was 26.5 months (range 10.75–54 months). Results: The patients were divided into 2 groups based on systemic ventricle morphology. Seventy-four patients were included in the left morphology group and 88 in the right morphology group. There was no difference in 10-year survival rates between the two type of systemic ventricle morphology. Postoperative thromboembolic events influenced the 10-year survival rate after the Fontan procedure (hazard ratio 4.84, 95% confidence interval: 1.26–18.55, p = 0.021). Conclusion: Systemic ventricle morphology was not associated with the 10-year survival rate after the Fontan procedure. Postoperative thromboembolic events accounted for a 4.84-times higher mortality risk after the Fontan procedure.

Original languageEnglish
Pages (from-to)677-684
Number of pages8
JournalAsian Cardiovascular and Thoracic Annals
Volume26
Issue number9
DOIs
Publication statusPublished - 1 Nov 2018

Keywords

  • congenital
  • Fontan procedure
  • Heart bypass
  • Heart defects
  • Heart ventricles
  • right
  • Risk factors
  • Survival analysis

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