TY - GEN
T1 - Synthesis Schiff Base of Isatin Derivatives Catalyzed by Iron (III) Trifluoromethanesulfonate
AU - Ismail, Rahmadillah
AU - Yunarti, Rika Tri
AU - Cahyana, Antonius Herry
N1 - Funding Information:
This research gets funded by the HIBAH PDUPT Menristek BRIN Nomor: NKB-157/UN2.RST/HKP.05.00/2021.
Publisher Copyright:
© 2022 American Institute of Physics Inc.. All rights reserved.
PY - 2022/8/18
Y1 - 2022/8/18
N2 - Isatin is a special heterocyclic compound because of its various biological activities. This research aims to synthesize isatin derivatives catalyzed by iron (III) trifluoromethanesulfonate, Fe(OTf)3. In this study, Fe(OTf)3 catalysts were synthesized using Fe3+ ions and Lewis acid and characterized by Fourier transform infrared (FTIR) spectroscopy, X-ray Diffraction (XRD), and Transmission ElectronMicroscope (TEM). The characterization results showed that the catalyst Fe(OTf)3 was successfully formed. Furthermore, Fe(OTf)3 catalysts were applied in the synthesis of isatin derivatives. Schiff base of isatin is a group of organic compounds with azomethine groups that play an essential role in biological systems and act as ligands in developing new chemical entities. The Schiff base of isatin is the product of condensation between the carbonyl compounds of isatin with different aromatic primary amines. In this paper, the synthesis of several Schiff bases of isatin derivatives applies conventional heating methods. The results were described by physicochemical analysis and characterized using UV-Vis spectrophotometry, FT-IR, and LC-MS. The characterization results support the successful synthesis of the isatin compound derivative.
AB - Isatin is a special heterocyclic compound because of its various biological activities. This research aims to synthesize isatin derivatives catalyzed by iron (III) trifluoromethanesulfonate, Fe(OTf)3. In this study, Fe(OTf)3 catalysts were synthesized using Fe3+ ions and Lewis acid and characterized by Fourier transform infrared (FTIR) spectroscopy, X-ray Diffraction (XRD), and Transmission ElectronMicroscope (TEM). The characterization results showed that the catalyst Fe(OTf)3 was successfully formed. Furthermore, Fe(OTf)3 catalysts were applied in the synthesis of isatin derivatives. Schiff base of isatin is a group of organic compounds with azomethine groups that play an essential role in biological systems and act as ligands in developing new chemical entities. The Schiff base of isatin is the product of condensation between the carbonyl compounds of isatin with different aromatic primary amines. In this paper, the synthesis of several Schiff bases of isatin derivatives applies conventional heating methods. The results were described by physicochemical analysis and characterized using UV-Vis spectrophotometry, FT-IR, and LC-MS. The characterization results support the successful synthesis of the isatin compound derivative.
UR - http://www.scopus.com/inward/record.url?scp=85137523190&partnerID=8YFLogxK
U2 - 10.1063/5.0104134
DO - 10.1063/5.0104134
M3 - Conference contribution
AN - SCOPUS:85137523190
T3 - AIP Conference Proceedings
BT - 9th International Conference of the Indonesian Chemical Society, ICICS 2021
A2 - Savalas, Lalu Rudyat Telly
A2 - Hadisaputra, Saprizal
PB - American Institute of Physics Inc.
T2 - 9th International Conference of the Indonesian Chemical Society: Toward a Meaningful Society, ICICS 2021
Y2 - 11 August 2021 through 13 August 2021
ER -