Synthesis of spirooxindole-pyrrolizidine compounds using fe3o4-go catalyst and their bioactivity assays

Mutiara Hapsari, Antonius Herry Cahyana, Syntia H. Oktavia, Agus Rimus Liandi

Research output: Contribution to journalArticlepeer-review

Abstract

Spirooxindole-pyrrolizidine is an essential compound of concern for researchers, especially in its structure which shows some existing bioactivities in medicine. A novel series of spirooxindole-pyrrolizidine were prepared by a onepot multicomponent reaction method. The reaction occurred between α, β-carbonyl unsaturated, isatin, and l-proline through 1,3-dipolar cycloaddition reaction and assisted by Fe3O4-graphene oxide (GO) as a catalyst. The spectral and analytical data have established the structures of new compounds and the catalyst used. The results of the reaction and data analysis showed that two spirooxindole-pyrrolizidine derivatives had been successfully synthesized. The newly synthesized compounds have been tested for their antioxidant and antimicrobial activity.

Original languageEnglish
Pages (from-to)2317-2324
Number of pages8
JournalRasayan Journal of Chemistry
Volume13
Issue number4
DOIs
Publication statusPublished - 1 Oct 2020

Keywords

  • 1,3-dipolar-cycloaddition
  • FeO
  • Graphene Oxide
  • Pyrrolizidine
  • Spiro-oxindole

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