Synthesis of pyrazolone derivatives compound using nanomagnetic Fe3O4catalyst from waste cooking oil and iron rust and antioxidant activity test

S. Pratiwi, A. H. Cahyana

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Pyrazolone derivates are compounds that widely found in biological activity. Thus, this compound commonly used in drugs production and product synthesis. In this study, pyrazolone derivatives were synthesized by Fe3O4 nano magnetic catalyst. The nano-magnetic Fe3O4 catalyst is made from iron rust and used cooking oil. Synthesis of nanomagnetic Fe3O4 is supported by characterization analysis using FTIR, XRD, EDS and SEM. Edaravone is a pyrazolone compound synthesized with ethyl acetoacetate and phenyl hydrazine. Edaravone produces a yield of 98.55 %. The synthesis pyrazolone derivate is done by mixing edaravone and aryl aldehyde like cinnamaldehyde, benzaldehyde, and 2-hydroxy-benzaldehyde. Compounds 1 and 3 were synthesized under optimum conditions. Nevertheless, compound 2 was synthesized with optimum time and temperature using 10 % by weight of the catalyst. Compound 1, compound 2, and compound 3 yields were 48.8 %, 30.4 %, and 16.04 % respectively. The formed products were determined by TLC, FTIR, UV-Vis and GC-MS. Antioxidant activity tests were carried out using compound 1, 2, and 3 with concentrations of 250 ppm.

Original languageEnglish
Title of host publicationProceedings of the 6th International Symposium on Current Progress in Mathematics and Sciences 2020, ISCPMS 2020
EditorsTribidasari A. Ivandini, David G. Churchill, Youngil Lee, Yatimah Binti Alias, Chris Margules
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735441132
DOIs
Publication statusPublished - 23 Jul 2021
Event6th International Symposium on Current Progress in Mathematics and Sciences 2020, ISCPMS 2020 - Depok, Indonesia
Duration: 27 Oct 202028 Oct 2020

Publication series

NameAIP Conference Proceedings
Volume2374
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference6th International Symposium on Current Progress in Mathematics and Sciences 2020, ISCPMS 2020
Country/TerritoryIndonesia
CityDepok
Period27/10/2028/10/20

Keywords

  • and antioxidant activity
  • aryl aldehyde
  • Nano-FeO
  • pyrazolone

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