Pyranopyrazole is a heterocyclic organic compound in which the skeleton is a pyran ring substituted by pyrazole in the ortho position. Pyranopyrazole can be synthesized using aldehyde, hydrazine, ethyl acetoacetate, and malononitrile as precursors with a multicomponent reaction method. Synthesis of pyranopyrazole is carried out through the Knoevenagel condensation reaction, Michael's addition, and cyclization. In this research, nano-Fe3O4 is synthesized from rust and used cooking oil. Synthesis of pyranopyrazole derivate compound reached the optimal condition within 60 min of the reaction with the amount of nano-Fe3O4 catalyst is 1 % (w/w). Benzaldehyde, 2-hydroxybenzaldehyde, and cinnamaldehyde are used in variations of aldehyde in this research. The results show that the reaction in 60 min using nano-Fe3O4 produces pyranopyrazole derivative compounds. The nano-Fe3O4 is characterized using FTIR, XRD, and SEM-EDS instruments. The resulting products are characterized by FTIR, UV-Visible, and GC-MS.