TY - GEN
T1 - Synthesis of Phenolipid Compound Obtained by Lipophilization of Gallic Acid with Ricinoleic Acid and its Activity Assay as an Antioxidant, Antimicrobial, and Emulsifier Agent
AU - Hasanah, Uswatun
AU - Handayani, Sri
AU - Hudiyono, Sumi
N1 - Funding Information:
The author would like to thank UI-CHEM Laboratory and the Chemistry Department for helping and providing facilities for the author. This research was funded by the International Indexed Publication (PUTI) Proceedings of 2020, Universitas Indonesia No. NKB-1023/UN2.RST/HKP.05.00/2020.
Funding Information:
The author would like to thank UI-CHEM Laboratory and the Chemistry Department for helping and providing facilities for the author. This research was funded by the International Indexed Publication (PUTI) Proceedings of 2020, Universitas Indonesia No. NKB-1023 / UN2.RST / HKP.05.00 / 2020.
Publisher Copyright:
© 2022 American Institute of Physics Inc.. All rights reserved.
PY - 2022/8/18
Y1 - 2022/8/18
N2 - Synthesis of ricinoleic acid-based phenolipid compound has been carried out by lipophilization of gallic acid with ricinoleic acid. Before lipophilization was carried out, ricinoleic acid was methylated first. The resulting methyl ricinoleic was then reacted with gallic acid using ZnCl2 as a catalyst at 70-80 RC for 6 hours in a reflux system. The synthesized product was characterized using Thin Layer Chromatography with a mixture of chloroform: methanol (93:7) used as the eluent. The phenolipid reaction product showed a higher Rf value (0.84) compared to the Rf value of methyl ricinoleic (0.76) or ricinoleic acid (0.58). Characterization of the synthesized product using FT-IR showed a new strong absorption band at wave number 758.06 cm-1 which indicated the presence of an aromatic C-H group (bend). It indicated that the phenolipid was produced. Antioxidant activity test of phenolipid compound using DPPH method showed the inhibition percentage value of 33% at the concentration of 2 mM. This value is lower than the inhibition percentage value of BHT (89.6%) used as control. The emulsifier test of the synthesized phenolipid compound showed good emulsion stability up to 24 hours observation, with water in oil (W/O) type of emulsion formed. The phenolipid compound showed medium antibacterial activity against Staphylococcus epidermidis and Propionibacterium acnes, which produced an inhibition zone up to 18 mm using the paper disc method. Still, it did not show antifungal activity against Candida albicans.
AB - Synthesis of ricinoleic acid-based phenolipid compound has been carried out by lipophilization of gallic acid with ricinoleic acid. Before lipophilization was carried out, ricinoleic acid was methylated first. The resulting methyl ricinoleic was then reacted with gallic acid using ZnCl2 as a catalyst at 70-80 RC for 6 hours in a reflux system. The synthesized product was characterized using Thin Layer Chromatography with a mixture of chloroform: methanol (93:7) used as the eluent. The phenolipid reaction product showed a higher Rf value (0.84) compared to the Rf value of methyl ricinoleic (0.76) or ricinoleic acid (0.58). Characterization of the synthesized product using FT-IR showed a new strong absorption band at wave number 758.06 cm-1 which indicated the presence of an aromatic C-H group (bend). It indicated that the phenolipid was produced. Antioxidant activity test of phenolipid compound using DPPH method showed the inhibition percentage value of 33% at the concentration of 2 mM. This value is lower than the inhibition percentage value of BHT (89.6%) used as control. The emulsifier test of the synthesized phenolipid compound showed good emulsion stability up to 24 hours observation, with water in oil (W/O) type of emulsion formed. The phenolipid compound showed medium antibacterial activity against Staphylococcus epidermidis and Propionibacterium acnes, which produced an inhibition zone up to 18 mm using the paper disc method. Still, it did not show antifungal activity against Candida albicans.
UR - http://www.scopus.com/inward/record.url?scp=85137460201&partnerID=8YFLogxK
U2 - 10.1063/5.0104063
DO - 10.1063/5.0104063
M3 - Conference contribution
AN - SCOPUS:85137460201
T3 - AIP Conference Proceedings
BT - 9th International Conference of the Indonesian Chemical Society, ICICS 2021
A2 - Savalas, Lalu Rudyat Telly
A2 - Hadisaputra, Saprizal
PB - American Institute of Physics Inc.
T2 - 9th International Conference of the Indonesian Chemical Society: Toward a Meaningful Society, ICICS 2021
Y2 - 11 August 2021 through 13 August 2021
ER -