Synthesis of Phenolipid Compound Obtained by Lipophilization of Gallic Acid with Ricinoleic Acid and its Activity Assay as an Antioxidant, Antimicrobial, and Emulsifier Agent

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Abstract

Synthesis of ricinoleic acid-based phenolipid compound has been carried out by lipophilization of gallic acid with ricinoleic acid. Before lipophilization was carried out, ricinoleic acid was methylated first. The resulting methyl ricinoleic was then reacted with gallic acid using ZnCl2 as a catalyst at 70-80 RC for 6 hours in a reflux system. The synthesized product was characterized using Thin Layer Chromatography with a mixture of chloroform: methanol (93:7) used as the eluent. The phenolipid reaction product showed a higher Rf value (0.84) compared to the Rf value of methyl ricinoleic (0.76) or ricinoleic acid (0.58). Characterization of the synthesized product using FT-IR showed a new strong absorption band at wave number 758.06 cm-1 which indicated the presence of an aromatic C-H group (bend). It indicated that the phenolipid was produced. Antioxidant activity test of phenolipid compound using DPPH method showed the inhibition percentage value of 33% at the concentration of 2 mM. This value is lower than the inhibition percentage value of BHT (89.6%) used as control. The emulsifier test of the synthesized phenolipid compound showed good emulsion stability up to 24 hours observation, with water in oil (W/O) type of emulsion formed. The phenolipid compound showed medium antibacterial activity against Staphylococcus epidermidis and Propionibacterium acnes, which produced an inhibition zone up to 18 mm using the paper disc method. Still, it did not show antifungal activity against Candida albicans.

Original languageEnglish
Title of host publication9th International Conference of the Indonesian Chemical Society, ICICS 2021
Subtitle of host publicationToward a Meaningful Society
EditorsLalu Rudyat Telly Savalas, Saprizal Hadisaputra
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735443808
DOIs
Publication statusPublished - 18 Aug 2022
Event9th International Conference of the Indonesian Chemical Society: Toward a Meaningful Society, ICICS 2021 - Mataram-Lombok, Indonesia
Duration: 11 Aug 202113 Aug 2021

Publication series

NameAIP Conference Proceedings
Volume2638
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference9th International Conference of the Indonesian Chemical Society: Toward a Meaningful Society, ICICS 2021
Country/TerritoryIndonesia
CityMataram-Lombok
Period11/08/2113/08/21

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