Synthesis of oxidized ricinoleic acid esters as antimicrobial and emulsifier compounds

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Ricinoleic acid is the main fatty acid constituent of castor oil which has antimicrobial activity. Research on the use of ricinoleic acid in ester form is more widely carried out, because it has a higher antimicrobial activity. In this study, commercial ricinoleic acid was oxidized using KMnO4 before it was used for esterification. The ester synthesis was carried out by reacting oxidized ricinoleic acid with acetic acid, lauric acid, or oleic acid at 60°C for 6 hours using ZnCl2 as catalyst. The molar ratio oxidized ricinoleic acid to varied carboxylic acids was 3:1. The ester products were then characterized using FTIR and examined as antimicrobial assay against Staphylococcus epidermidis and Propionibacterium acnes. Emulsifier test was performed to observe the stability and emulsion type, using ester products as emulsifier. FTIR spectra showed a typical absorption band of C-O ester which indicates that oxidized ricinoleic acid esters had been successfully formed. The antimicrobial activity assay showed positive results against the growth of Propionibacterium acnes and Staphylococcus epidermidis. Oxidized ricinoleic-lauric ester showed the highest antimicrobial activity against Staphylococcus epidermidis. The emulsifier test showed that the three esters had ability to stabilize emulsion up to 24 hours for water-in-oil (w/o) emulsion type.

Original languageEnglish
Title of host publication8th International Conference of the Indonesian Chemical Society, ICICS 2019
EditorsMohamad Rafi, Rudi Heryanto, Wulan Tri Wahyuni
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735420021
DOIs
Publication statusPublished - 4 Jun 2020
Event8th International Conference of the Indonesian Chemical Society 2019, ICICS 2019 - Bogor, Indonesia
Duration: 6 Aug 20197 Aug 2019

Publication series

NameAIP Conference Proceedings
Volume2243
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference8th International Conference of the Indonesian Chemical Society 2019, ICICS 2019
CountryIndonesia
CityBogor
Period6/08/197/08/19

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    Puspa, A. O., Handayani, S., Setiasih, S., & Hudiyono, S. (2020). Synthesis of oxidized ricinoleic acid esters as antimicrobial and emulsifier compounds. In M. Rafi, R. Heryanto, & W. T. Wahyuni (Eds.), 8th International Conference of the Indonesian Chemical Society, ICICS 2019 [020018] (AIP Conference Proceedings; Vol. 2243). American Institute of Physics Inc.. https://doi.org/10.1063/5.0001341