Synthesis of 1,4-dihydropiridine with aromatic of cinnamaldehyde compound using nife2o4 mnps catalyst and the activity test as antioxidant

Antonius Herry Cahyana, Agus Rimus Liandi, Yuni Safitri, Rika Tri Yunarti

Research output: Contribution to journalArticlepeer-review


1,4-dihydropyridine (DHPs) is a class of compounds that are significantly present in a variety of natural products and commercial medicines such as felodipine. This study aims to modify cinnamaldehyde to become derivatives of 1,4-dihydropyridine using NiFe2O4 MNPs as the catalyst. NiFe2O4 MNPs were synthesized by the co-precipitation method using a 2:1 molar ratio between ferrite nitrate and nickel nitrate and analyzed by XRD and SEM-EDX. The results of the characterization support that NiFe2O4 MNPs were successfully synthesized. After that, NiFe2O4 was tested for its ability as a catalyst in the synthesis of 1,4 dihydropyridine. The synthesis results are confirmed with MP apparatus, UV/Vis Spectrophotometry, FT-IR and GC-MS, and obtained three 1,4-dihydropyridine compounds, namely 2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester (compound 1), 2,6-dimethyl-4-styryl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester (compound 2), and 4-(4-Hydroxy-phenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester (compound 3). The ability NiFe2O4 as catalyst gives a significant difference yield between the reaction with and without the catalyst.

Original languageEnglish
Pages (from-to)1491-1497
Number of pages7
JournalRasayan Journal of Chemistry
Issue number3
Publication statusPublished - 1 Jul 2020


  • 1,4-Dihydropyridine
  • Antioxidant
  • Cinnamaldehyde
  • Nanocatalyst
  • NiFeO


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