@inproceedings{0c8bc86dfe2d46968ba268263e012d6a,
title = "Synthesis, characterization and in vitro release study of efavirenz-loaded chitosan nanoparticle",
abstract = "Nanopolymer-based delivery system is widely developed to enhance the solubility and bioavailability of drugs. One of them, Chitosan is a biocompatible, biodegradable and non toxic natural polymer. Other points, efavirenz is well known as a drug with low solubility in water and variable bioavailability less than 45 %. In this study, efavirenz was loaded into chitosan nanoparticle by ionotropic gelation method. Efavirenz-loaded chitosan nanoparticle (efavirenz-CNP) was prepared using low molecular weight chitosan (85 % deacetylated) and tripolyphosphate as a cross-linking agent. Efavirenz-CNP has particle size ±104 nm with Zeta potential value of -30.7 mV. As the results, the entrapment efficiency and loading capacity of efavirenz-CNP was 91.09 and 38.71 %, respectively. The in vitro drug release of efavirenz-CNP in buffer phosphate at pH of 7.4 reached 69.05 % for 24 h.",
keywords = "chitosan, drug delivery, efavirenz, in vitro release, Nanopolymer",
author = "R. Rozana and Y. Yulizar and A. Saefumillah and Apriandanu, {D. O.B.}",
note = "Publisher Copyright: {\textcopyright} 2020 Author(s).; 5th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2019 ; Conference date: 09-07-2019 Through 10-07-2019",
year = "2020",
month = jun,
day = "1",
doi = "10.1063/5.0007923",
language = "English",
series = "AIP Conference Proceedings",
publisher = "American Institute of Physics Inc.",
editor = "Terry Mart and Djoko Triyono and Ivandini, {Tribidasari Anggraningrum}",
booktitle = "Proceedings of the 5th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2019",
address = "United States",
}