Synthesis, characterization and in vitro release study of efavirenz-loaded chitosan nanoparticle

R. Rozana; Y. Yulizar; A. Saefumillah; D. O.B. Apriandanu

doi:10.1063/5.0007923

Synthesis, characterization and in vitro release study of efavirenz-loaded chitosan nanoparticle

R. Rozana, Y. Yulizar, A. Saefumillah, D. O.B. Apriandanu

Department of Chemistry

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Citation (Scopus)

Abstract

Nanopolymer-based delivery system is widely developed to enhance the solubility and bioavailability of drugs. One of them, Chitosan is a biocompatible, biodegradable and non toxic natural polymer. Other points, efavirenz is well known as a drug with low solubility in water and variable bioavailability less than 45 %. In this study, efavirenz was loaded into chitosan nanoparticle by ionotropic gelation method. Efavirenz-loaded chitosan nanoparticle (efavirenz-CNP) was prepared using low molecular weight chitosan (85 % deacetylated) and tripolyphosphate as a cross-linking agent. Efavirenz-CNP has particle size ±104 nm with Zeta potential value of -30.7 mV. As the results, the entrapment efficiency and loading capacity of efavirenz-CNP was 91.09 and 38.71 %, respectively. The in vitro drug release of efavirenz-CNP in buffer phosphate at pH of 7.4 reached 69.05 % for 24 h.

Original language	English
Title of host publication	Proceedings of the 5th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2019
Editors	Terry Mart, Djoko Triyono, Tribidasari Anggraningrum Ivandini
Publisher	American Institute of Physics Inc.
ISBN (Electronic)	9780735420014
DOIs	https://doi.org/10.1063/5.0007923
Publication status	Published - 1 Jun 2020
Event	5th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2019 - Depok, Indonesia Duration: 9 Jul 2019 → 10 Jul 2019

Publication series

Name	AIP Conference Proceedings
Volume	2242
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Conference

Conference	5th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2019
Country/Territory	Indonesia
City	Depok
Period	9/07/19 → 10/07/19

Keywords

chitosan
drug delivery
efavirenz
in vitro release
Nanopolymer

Access to Document

10.1063/5.0007923

Cite this

Rozana, R., Yulizar, Y., Saefumillah, A., & Apriandanu, D. O. B. (2020). Synthesis, characterization and in vitro release study of efavirenz-loaded chitosan nanoparticle. In T. Mart, D. Triyono, & T. A. Ivandini (Eds.), Proceedings of the 5th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2019 [040004] (AIP Conference Proceedings; Vol. 2242). American Institute of Physics Inc.. https://doi.org/10.1063/5.0007923

Rozana, R. ; Yulizar, Y. ; Saefumillah, A. et al. / Synthesis, characterization and in vitro release study of efavirenz-loaded chitosan nanoparticle. Proceedings of the 5th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2019. editor / Terry Mart ; Djoko Triyono ; Tribidasari Anggraningrum Ivandini. American Institute of Physics Inc., 2020. (AIP Conference Proceedings).

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title = "Synthesis, characterization and in vitro release study of efavirenz-loaded chitosan nanoparticle",

abstract = "Nanopolymer-based delivery system is widely developed to enhance the solubility and bioavailability of drugs. One of them, Chitosan is a biocompatible, biodegradable and non toxic natural polymer. Other points, efavirenz is well known as a drug with low solubility in water and variable bioavailability less than 45 %. In this study, efavirenz was loaded into chitosan nanoparticle by ionotropic gelation method. Efavirenz-loaded chitosan nanoparticle (efavirenz-CNP) was prepared using low molecular weight chitosan (85 % deacetylated) and tripolyphosphate as a cross-linking agent. Efavirenz-CNP has particle size ±104 nm with Zeta potential value of -30.7 mV. As the results, the entrapment efficiency and loading capacity of efavirenz-CNP was 91.09 and 38.71 %, respectively. The in vitro drug release of efavirenz-CNP in buffer phosphate at pH of 7.4 reached 69.05 % for 24 h.",

keywords = "chitosan, drug delivery, efavirenz, in vitro release, Nanopolymer",

author = "R. Rozana and Y. Yulizar and A. Saefumillah and Apriandanu, {D. O.B.}",

note = "Funding Information: The authors would like to thank Universitas Indonesia for funding this research through PIT-9 Grant Universitas Indonesia with contract number: NKB-0037/UN2.R3.1/HKP.05.00/2019 and National Agency of Drug and Food Control-Republic of Indonesia. Publisher Copyright: {\textcopyright} 2020 Author(s).; 5th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2019 ; Conference date: 09-07-2019 Through 10-07-2019",

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doi = "10.1063/5.0007923",

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Rozana, R, Yulizar, Y , Saefumillah, A & Apriandanu, DOB 2020, Synthesis, characterization and in vitro release study of efavirenz-loaded chitosan nanoparticle. in T Mart, D Triyono & TA Ivandini (eds), Proceedings of the 5th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2019., 040004, AIP Conference Proceedings, vol. 2242, American Institute of Physics Inc., 5th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2019, Depok, Indonesia, 9/07/19. https://doi.org/10.1063/5.0007923

Synthesis, characterization and in vitro release study of efavirenz-loaded chitosan nanoparticle. / Rozana, R.; Yulizar, Y.; Saefumillah, A. et al.
Proceedings of the 5th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2019. ed. / Terry Mart; Djoko Triyono; Tribidasari Anggraningrum Ivandini. American Institute of Physics Inc., 2020. 040004 (AIP Conference Proceedings; Vol. 2242).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Synthesis, characterization and in vitro release study of efavirenz-loaded chitosan nanoparticle

AU - Rozana, R.

AU - Yulizar, Y.

AU - Saefumillah, A.

AU - Apriandanu, D. O.B.

N1 - Funding Information: The authors would like to thank Universitas Indonesia for funding this research through PIT-9 Grant Universitas Indonesia with contract number: NKB-0037/UN2.R3.1/HKP.05.00/2019 and National Agency of Drug and Food Control-Republic of Indonesia. Publisher Copyright: © 2020 Author(s).

PY - 2020/6/1

Y1 - 2020/6/1

N2 - Nanopolymer-based delivery system is widely developed to enhance the solubility and bioavailability of drugs. One of them, Chitosan is a biocompatible, biodegradable and non toxic natural polymer. Other points, efavirenz is well known as a drug with low solubility in water and variable bioavailability less than 45 %. In this study, efavirenz was loaded into chitosan nanoparticle by ionotropic gelation method. Efavirenz-loaded chitosan nanoparticle (efavirenz-CNP) was prepared using low molecular weight chitosan (85 % deacetylated) and tripolyphosphate as a cross-linking agent. Efavirenz-CNP has particle size ±104 nm with Zeta potential value of -30.7 mV. As the results, the entrapment efficiency and loading capacity of efavirenz-CNP was 91.09 and 38.71 %, respectively. The in vitro drug release of efavirenz-CNP in buffer phosphate at pH of 7.4 reached 69.05 % for 24 h.

AB - Nanopolymer-based delivery system is widely developed to enhance the solubility and bioavailability of drugs. One of them, Chitosan is a biocompatible, biodegradable and non toxic natural polymer. Other points, efavirenz is well known as a drug with low solubility in water and variable bioavailability less than 45 %. In this study, efavirenz was loaded into chitosan nanoparticle by ionotropic gelation method. Efavirenz-loaded chitosan nanoparticle (efavirenz-CNP) was prepared using low molecular weight chitosan (85 % deacetylated) and tripolyphosphate as a cross-linking agent. Efavirenz-CNP has particle size ±104 nm with Zeta potential value of -30.7 mV. As the results, the entrapment efficiency and loading capacity of efavirenz-CNP was 91.09 and 38.71 %, respectively. The in vitro drug release of efavirenz-CNP in buffer phosphate at pH of 7.4 reached 69.05 % for 24 h.

KW - chitosan

KW - drug delivery

KW - efavirenz

KW - in vitro release

KW - Nanopolymer

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DO - 10.1063/5.0007923

M3 - Conference contribution

AN - SCOPUS:85086674769

T3 - AIP Conference Proceedings

BT - Proceedings of the 5th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2019

A2 - Mart, Terry

A2 - Triyono, Djoko

A2 - Ivandini, Tribidasari Anggraningrum

PB - American Institute of Physics Inc.

T2 - 5th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2019

Y2 - 9 July 2019 through 10 July 2019

ER -

Rozana R, Yulizar Y , Saefumillah A, Apriandanu DOB. Synthesis, characterization and in vitro release study of efavirenz-loaded chitosan nanoparticle. In Mart T, Triyono D, Ivandini TA, editors, Proceedings of the 5th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2019. American Institute of Physics Inc. 2020. 040004. (AIP Conference Proceedings). doi: 10.1063/5.0007923

Synthesis, characterization and in vitro release study of efavirenz-loaded chitosan nanoparticle

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