Synthesis, characterization and in vitro release study of efavirenz-loaded chitosan nanoparticle

R. Rozana, Y. Yulizar, A. Saefumillah, D. O.B. Apriandanu

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Nanopolymer-based delivery system is widely developed to enhance the solubility and bioavailability of drugs. One of them, Chitosan is a biocompatible, biodegradable and non toxic natural polymer. Other points, efavirenz is well known as a drug with low solubility in water and variable bioavailability less than 45 %. In this study, efavirenz was loaded into chitosan nanoparticle by ionotropic gelation method. Efavirenz-loaded chitosan nanoparticle (efavirenz-CNP) was prepared using low molecular weight chitosan (85 % deacetylated) and tripolyphosphate as a cross-linking agent. Efavirenz-CNP has particle size ±104 nm with Zeta potential value of -30.7 mV. As the results, the entrapment efficiency and loading capacity of efavirenz-CNP was 91.09 and 38.71 %, respectively. The in vitro drug release of efavirenz-CNP in buffer phosphate at pH of 7.4 reached 69.05 % for 24 h.

Original languageEnglish
Title of host publicationProceedings of the 5th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2019
EditorsTerry Mart, Djoko Triyono, Tribidasari Anggraningrum Ivandini
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735420014
DOIs
Publication statusPublished - 1 Jun 2020
Event5th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2019 - Depok, Indonesia
Duration: 9 Jul 201910 Jul 2019

Publication series

NameAIP Conference Proceedings
Volume2242
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference5th International Symposium on Current Progress in Mathematics and Sciences, ISCPMS 2019
Country/TerritoryIndonesia
CityDepok
Period9/07/1910/07/19

Keywords

  • chitosan
  • drug delivery
  • efavirenz
  • in vitro release
  • Nanopolymer

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