Synthesis, anti-inflammatory and antioxidant activity of mannich bases of dehydrozingerone derivatives

Hayun Hayun, Arif Arrahman, Euis Maras Purwati, Arry Yanuar, Fransisca Fortunata, Freddyhan Suhargo, Discka Winda Syafiqah, Carissa Ignacia, Agnes Rebecca Novalia

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Objective: This study aims to synthesize a series of five new Mannich bases of dehydrozingerone (DHZ) derivatives and to evaluate for their antiinflammatory and antioxidant activity. Methods:The synthesis was performed by refluxing DHZ with formaldehyde and secondary amines, and the structures of the synthesized compounds were confirmed by FT-IR,1H-NMR,13C-NMR, and HR-MS.The anti-inflammatory and antioxidant activity evaluations were done by inhibition of heat-induced albumin denaturation and a free-radical DPPH method, respectively. Results: All the synthesized compounds (2a-e) showed anti-inflammatory and antioxidant activity. The highest anti-inflammatory activity was shown by compound 2c.The activity was comparable to the that of diclofenac sodium as a standard. While, the highest antioxidant activity was demostrated by compound 2e. The compound showed moderate activity compared to that of quercetin as a standard. Mostly of Mannich base derivatives of DHZ compounds exhibited higher antioxidant activity than that of DHZ. Conclusion: A series of five new Mannich bases of DHZ (2a-e) was synthesized successfully. Compound 2c demonstrated anti-inflammatory activity which was comparable to diclofenac sodium, while compound 2e exhibited moderate antioxidant activity compared to quercetin as standard.

Original languageEnglish
Pages (from-to)s6-s10
JournalJournal of Young Pharmacists
Issue number2
Publication statusPublished - 1 Apr 2018


  • Anti-inflammatory
  • Antioxidant
  • Dehydrozingerone
  • Mannich bases
  • Synthesis


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