Synthesis and preliminary in vitro anti-inflammatory evaluation of mannich bases derivatives of 4'-methoxy-substituted of asymmetrical cyclovalone analogs

Nur Rahmawati, Hariyanti Hariyanti, Fadlina Chany Saputri, Hayun Hayun

Research output: Contribution to journalArticle

Abstract

Two of Mannich bases derivatives of 4'-methoxy-substituted of asymmetrical cyclovalone analog (ACA) (2a and 2b) were synthesized. The synthesized compounds and the other two Mannich bases derivatives of 4'-methoxy-substituted ACA (2c and 2d) were evaluated for their in-vitro antiinflammatory activity preliminary by protein denaturation inhibition method using a final concentration of 1.57 μM. The study found that all the Mannich bases exhibited anti-inflammatory potential with inhibition ranging from 33.17- 42.47%. The activity of 2b (42,47%) and 2d (41.90%) was higher than that of diclofenac sodium (35.27%) and the parent compound 1 (38.16%). As a conclusion, 2b and 2d have a prospect as a potential candidate for an anti-inflammatory agent. Further study should be done using more specific methods.

Original languageEnglish
Pages (from-to)35-41
Number of pages7
JournalIndonesian Journal of Pharmacy
Volume31
Issue number1
DOIs
Publication statusPublished - 1 Jan 2020

Keywords

  • Asymmetrical
  • Ayclovalone
  • In-vitro anti-inflammatory
  • Mannich bases derivatives
  • Protein denaturation
  • Synthesis

Fingerprint Dive into the research topics of 'Synthesis and preliminary in vitro anti-inflammatory evaluation of mannich bases derivatives of 4'-methoxy-substituted of asymmetrical cyclovalone analogs'. Together they form a unique fingerprint.

  • Cite this