Synthesis and optimization of acrylic-N-acryloxysuccinimide copolymer microspheres

Alizar Ulianas, Nurlely, Yulkifli, Lee Yook Heng, Tan Ling Ling

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


A micro-sized poly(n-butyl acrylate-co-N-acryloxysuccinimide) [poly(nBA-co-NAS] copolymer bio-carrier matrix has been synthesized from n-butyl acrylate (nBA) and N-acryloxysuccinimide (NAS) monomers through a single step emulsion photopolymerization protocol. Narrower size distribution of the copolymer microspheres having a size in the range of 0.31-1.04 μm was obtained using nBA-SDS composition ratio of 0.25:5.00 (mL: mg). The FTIR analysis result confirmed the presence of the useful succinimide functional groups on the poly(nBA-co-NAS), which rendered the copolymer microspheres a feasible alternative to other polymers for use as biological immobilization carrier for enzymes and DNA molecules in the fabrication of advanced biosensor devices. The low glass transition temperature (Tg) of the as-synthesized copolymer microspheres signifies the soft and good adhesion properties of the matrix to be attached to the solid support to form the miniature solid-state biosensing devices.

Original languageEnglish
Pages (from-to)780-784
Number of pages5
JournalInternational Journal on Advanced Science, Engineering and Information Technology
Issue number3
Publication statusPublished - 1 Jan 2018


  • Copolymer
  • Immobilization matrix
  • Microspheres
  • Photo-polymerization


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