Synthesis and characterization of starch acetate as microencapsulation agent for controlled release cefotaxime sodium

Shelvi Listiana, Endang Saepudin, Susi Kusumaningrum

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Starch acetate is a new starch based polymer for its application agent for controlling release cefotaxime sodium. Controlled release for oral cefotaxime are needed to stabilize cefotaxime sodium at pH of gastric, and to avoid irritating gastric with a degree of substitution of 2,75 could be synthesized by acetylation of cassava starch with acetic anhydride and acetic glacial using sodium hydroxide as catalyst. Starch acetate microcapsules of sodium cefotaxime were prepared by an emulsification-solvent evaporation method and the microcapsules were being studied evaluation of starch acetate as microencapsulating agent. The starch acetate microcapsules prepared are spherical shape. Microencapsulation efficiency depends on Degree substitution in 80,85 %.

Original languageEnglish
Title of host publication3rd International Conference on Chemistry, Chemical Process and Engineering, IC3PE 2020
EditorsIs Fatimah, Won-Chun Oh, Imam Sahroni
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735441262
DOIs
Publication statusPublished - 1 Sep 2021
Event3rd International Conference on Chemistry, Chemical Process and Engineering, IC3PE 2020 - Yogyakarta, Indonesia
Duration: 30 Sep 2020 → …

Publication series

NameAIP Conference Proceedings
Volume2370
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference3rd International Conference on Chemistry, Chemical Process and Engineering, IC3PE 2020
Country/TerritoryIndonesia
CityYogyakarta
Period30/09/20 → …

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