Synthesis and biological activity of 2-hydroxynicotinoyl-serine-butyl esters related to antibiotic UK-3A

Ade Arsianti, Muhammad Hanafi, Endang Saefudin, Tsumoru Morimoto, Kiyomi Kakiuchi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Novel 2-hydroxynicotinoyl-serine-butyl esters have been synthesized. Three-step reactions from l-serine by esterification with n-butanol, amidation with 2-hydroxynicotinic acid and esterification with the corresponding carboxylic acids gave AD-1, AD-2 and AD-3. The toxicity level of esters were determined by Brine shrimp assay, and antibiotic activity was tested against Escherichia coli, Bacillus subtilis, Staphylococcus aureus and Candida albicans. AD-3 showed greater activity as a growth inhibitor of B. subtilis and S. aureus compared to Antimycin A 3.

Original languageEnglish
Pages (from-to)4018-4020
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume20
Issue number14
DOIs
Publication statusPublished - 15 Jul 2010

Keywords

  • Antibiotic
  • Serine-butyl ester
  • Synthesis
  • UK-3A

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