@article{67972b78bd284b7cb483842e8a8d7feb,
title = "Synthesis and antioxidant activity study of new mannich bases derived from vanillic acid",
abstract = "We synthesized five new Mannich bases compounds from vanillic acid and evaluated for their antioxidant activities using a free-radical DPPH and FRAP methods. The compounds' structures were confirmed based on infrared, proton NMR, carbon NMR, and mass spectra. In this study, the compound 5-(pyrrolidin-1-ylmethyl)vanillic acid (2e) showed the best free-radical scavenger activity, while compound 2-[(diethylamino)methyl]vanillic acid (2c) showed the best as a ferric reductant. Mannich bases enhanced the free-radical scavenger activity but decreasing the ferric reduction potential of the parent compounds. The compounds were found to be moderate antioxidant agents.",
keywords = "Antioxidant, DPPH, FRAP, Mannich Bases, Synthesis, Vanillic Acid",
author = "H. Hayun and I. Gavrila and S. Silviana and Siahaan, {A. E.K.} and Vonna, {R. F.} and Latifah, {M. I.}",
note = "Funding Information: This work was funded by Universitas Indonesia, Depok, Indonesia (Research Grant, No.: 1768/UN2.R3.1/HKP.05.00/2018). Thanks to the Chemistry Department, Bandung Institute of Technology (ITB), Indonesia, for providing a recording of NMR and mass spectra. Funding Information: This work was funded by Universitas Indonesia, Depok, Indonesia (Research Grant, No.: 1768/UN2.R3.1/HKP.05.00/2018).Thanks to the Chemistry Department, Bandung Institute of Technology (ITB), Indonesia, for providing a recording of NMR and mass spectra. Publisher Copyright: {\textcopyright} RASĀYAN. All rights reserved.",
year = "2020",
month = jan,
day = "1",
doi = "10.31788/RJC.2020.1315300",
language = "English",
volume = "13",
pages = "131--138",
journal = "Rasayan Journal of Chemistry",
issn = "0974-1496",
publisher = "Rasayan Journal",
number = "1",
}