Synthesis and antioxidant activity study of new mannich bases derived from vanillic acid

H. Hayun, I. Gavrila, S. Silviana, A. E.K. Siahaan, R. F. Vonna, M. I. Latifah

Research output: Contribution to journalArticle

Abstract

We synthesized five new Mannich bases compounds from vanillic acid and evaluated for their antioxidant activities using a free-radical DPPH and FRAP methods. The compounds' structures were confirmed based on infrared, proton NMR, carbon NMR, and mass spectra. In this study, the compound 5-(pyrrolidin-1-ylmethyl)vanillic acid (2e) showed the best free-radical scavenger activity, while compound 2-[(diethylamino)methyl]vanillic acid (2c) showed the best as a ferric reductant. Mannich bases enhanced the free-radical scavenger activity but decreasing the ferric reduction potential of the parent compounds. The compounds were found to be moderate antioxidant agents.

Original languageEnglish
Pages (from-to)131-138
Number of pages8
JournalRasayan Journal of Chemistry
Volume13
Issue number1
DOIs
Publication statusPublished - 1 Jan 2020

Keywords

  • Antioxidant
  • DPPH
  • FRAP
  • Mannich Bases
  • Synthesis
  • Vanillic Acid

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