Abstract
A novel polyhydroxylated 18-membered analogue of antimycin A 3 was synthesized. Our synthesis commenced with Boc-l-threonine and was achieved by way of one-pot homocoupling/ring-closing olefin metathesis reaction cascade and Sharpless asymmetric dihydroxylation. The analogue exhibited a greater anticancer activity against HeLa cells, breast MDA-MB-231 cells, and prostate PC-3 cells compared to the original antimycin A 3.
Original language | English |
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Pages (from-to) | 2884-2891 |
Number of pages | 8 |
Journal | Tetrahedron |
Volume | 68 |
Issue number | 13 |
DOIs | |
Publication status | Published - 1 Apr 2012 |
Keywords
- Analogue
- Anticancer
- Antimycin A
- Polyhydroxylated 18-membered ring
- Synthesis