Synthesis and anticancer activity of polyhydroxylated 18-membered analogue of antimycin A 3

Ade Arsianti, Hiroki Tanimoto, Tsumoru Morimoto, Anton Bahtiar, Tatsuo Takeya, Kiyomi Kakiuchi

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

A novel polyhydroxylated 18-membered analogue of antimycin A 3 was synthesized. Our synthesis commenced with Boc-l-threonine and was achieved by way of one-pot homocoupling/ring-closing olefin metathesis reaction cascade and Sharpless asymmetric dihydroxylation. The analogue exhibited a greater anticancer activity against HeLa cells, breast MDA-MB-231 cells, and prostate PC-3 cells compared to the original antimycin A 3.

Original languageEnglish
Pages (from-to)2884-2891
Number of pages8
JournalTetrahedron
Volume68
Issue number13
DOIs
Publication statusPublished - 1 Apr 2012

Keywords

  • Analogue
  • Anticancer
  • Antimycin A
  • Polyhydroxylated 18-membered ring
  • Synthesis

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