Method: An observational study in Cipto Mangunkusumo Hospital was conducted. Patients with underlying
liver cirrhosis between March 2020-January 2021 with positive confirmation of COVID-19 were enrolled in this study. Liver cirrhosis patients without COVID-19 were enrolled as a comparison. Both liver cirrhosis patients with and without COVID-19 were follow up at the time of hospital admission until 30 days outcome. Kaplan Meier and a log-rank test were conducted to evaluate the comparison of survival rate in liver cirrhosis patients with and without COVID-19. Multivariate Cox Proportional Hazard was conducted to identify the independent risk factors related to survival.
Results: There were 22 liver cirrhosis patients with COVID-19 and 116 liver cirrhosis patients included in
this study. Presentation of gender and age similar both of them. Predominantly males with average age were 57 years ± 13,60 for cirrhosis with COVID-19 patients and 53 years ± 12,75 for without COVID-19. The survival rate of liver cirrhosis patients with COVID-19 lower than liver cirrhosis patients without COVID-19 (35.8% vs. 67.2%, p-value 0.001). Median survival of liver cirrhosis patients with COVID-19 was 4 days (95% CI: 1-8 days), while median survival of liver cirrhosis patients without COVID-19 couldn’t be reached since the survival rate of this group above 50%. Final model Cox PH showed that liver cirrhosis with COVID-19 (HR: 8.99; CI 95%: 4.55 – 17.80, p-value 0.001) and Child-Pugh class C (HR: 5.61; 95% CI: 2.76 – 11.40, p value 0.001) were the independent risk factors associated with poor survival.
Conclusion: The survival rate of liver cirrhosis patients with COVID-19 lower than liver cirrhosis patients
without COVID-19. Liver cirrhosis with COVID-19 and Child-Pugh class C were associated with poor survival.
|Journal||The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy|
|Publication status||Published - 2021|
- COVID-19, liver cirrhosis, survival rate