TY - JOUR
T1 - Supplementation of water extract of purple sweet potato (Ipomoeo Batatas L) in improving the EEG image, decreasing the seizure frequency and reducing the frequency of drugs resistant of focal epilepsy in children
AU - Suwarba, I. Gusti Ngurah Made
AU - Soetjiningsih,
AU - Bakta, I. Made
AU - Jawi, I. Made
AU - Sukrama, I. Dewa Made
AU - Yasa, I. Wayan Putu Sutirta
AU - Mangunatmadja, Irawan
N1 - Publisher Copyright:
This is an Open Access article licensed under a Creative Commons license: Attribution 4.0 International (CC-BY). Published by Oriental Scientific Publishing Company © 2019
PY - 2019/3/1
Y1 - 2019/3/1
N2 - The water extract of purple sweet potato contains of anthocyanin, a sub-class of flavonoid that has powerful antioxidant, antiinflammatory, and anticonvulsant effect. The aim of this study was to determine the effectiveness of supplementation of water extract of purple sweet potato towards recovery (remission) of drug resistant focal epilepsy (DRFE) in children with standard conventional antiepileptic medicine. It was found that the supplementation of purple sweet potato extract had a pure effect in improving all of the dependent variables, including decreased of the serum level of 8-OHdG by 1.611 pg/mL (p<0.001); decreased the serum level of IL-6 by 3.320 pg/mL (p<0.001); increased the total SOD serum level by 0.208 IU/ mL (p=0.003); improved the EEG image (p=0.004); and decreased the seizure frequency at the end of the sixth week by 3.972 times (p<0.001), compared to the control. There is a significant effect on the use of supplementation of purple sweet potato extract in decreasing the serum level of 8-OHdG, decreasing the serum level of IL-6, increasing the total SOD serum level, improving the EEG image, decreasing the seizure frequency at the end of the sixth week, which at the end reducing the frequency of drugs resistant of focal epilepsy in children.
AB - The water extract of purple sweet potato contains of anthocyanin, a sub-class of flavonoid that has powerful antioxidant, antiinflammatory, and anticonvulsant effect. The aim of this study was to determine the effectiveness of supplementation of water extract of purple sweet potato towards recovery (remission) of drug resistant focal epilepsy (DRFE) in children with standard conventional antiepileptic medicine. It was found that the supplementation of purple sweet potato extract had a pure effect in improving all of the dependent variables, including decreased of the serum level of 8-OHdG by 1.611 pg/mL (p<0.001); decreased the serum level of IL-6 by 3.320 pg/mL (p<0.001); increased the total SOD serum level by 0.208 IU/ mL (p=0.003); improved the EEG image (p=0.004); and decreased the seizure frequency at the end of the sixth week by 3.972 times (p<0.001), compared to the control. There is a significant effect on the use of supplementation of purple sweet potato extract in decreasing the serum level of 8-OHdG, decreasing the serum level of IL-6, increasing the total SOD serum level, improving the EEG image, decreasing the seizure frequency at the end of the sixth week, which at the end reducing the frequency of drugs resistant of focal epilepsy in children.
KW - Children
KW - DRFE
KW - Epilepsy
KW - Purple Sweet Potato
KW - Seizure
UR - http://www.scopus.com/inward/record.url?scp=85064653078&partnerID=8YFLogxK
U2 - 10.13005/bpj/1622
DO - 10.13005/bpj/1622
M3 - Article
AN - SCOPUS:85064653078
SN - 0974-6242
VL - 12
SP - 141
EP - 147
JO - Biomedical and Pharmacology Journal
JF - Biomedical and Pharmacology Journal
IS - 1
ER -