Subchronic Toxicity Studies of a Combined Andrographis paniculata (Burm.f.) Nees, Syzygium cumini (L) Skeels, and Caesalpinia sappan L Extract in Sprague-Dawley Rats

Atini Solawati, Berna Elya, Heri Setiawan, Raysa Yunda Pratiwi

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Andrographis paniculata, Syzygium cumini and Caesalpinia sappan (ASC) are plants that are widely used as traditional medicines in treating diabetes. The acute toxicity test results of the combination of these three plants were safe up to 5000 mg/Kg BB. Objectives: To evaluate subchronic toxicity of a combined ASC extract. Methods: Male and female Sprague Dawley rats were acclimatized for 14 days and then fed a normal diet with ASC extract at doses of 150, 575 and 1000 mg/kg BW daily for 135 days. At the end of the study, the rats were sacrificed and then blood, heart, pulmonary, liver, kidneys, spleen and pancreas were collected. Result: The results showed no abnormality in the experimental group compared with the control group. All values of other parameters assessed remained within the normal range. Conclusions: The combination of ASC extract given orally for 135 days to male and female rats did not show any subchronic toxicity.

Original languageEnglish
Pages (from-to)531-535
Number of pages5
JournalPharmacognosy Journal
Volume14
Issue number3
DOIs
Publication statusPublished - May 2022

Keywords

  • Andrographis paniculata
  • Caesalpinia sappan
  • Rats
  • Subchronic yoxicity
  • Syzygium cumini

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