Subacute oral toxicity test of chitosan-alginate coated microparticle of garcinia mangostana linn extract

Gede Bagus Yoga Satriadinatha, Siti Farida, Kamarza Mulia, Desak Gede Budi Krisnamurti

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Chitosan-alginate coated microparticle of Garcinia mangostana Linn extract promises an alternative treatment of colon cancer patients, as the component of Garcinia mangostana Linn extract has anticancer activity in colon cancer cell lines, and chitosan-alginate could deliver compound faster to colon and accelerate its absorption. However, there have not been any studies evaluating sub-acutely the toxicity effects of this compound on the liver (SGOT and SGPT) and clinical signs of toxicity. This study was conducted to evaluate the subacute toxicity effect of Chitosan-alginate coated microparticle of Garcinia mangostana Linn extract's oral administration. Fifty BALB/c mice were divided into five groups, including doses of 0.5 gram/kg, 1.0 gram/kg, 2.0 gram/kg, negative control, and normal group. Each rat was given an extract by force-feeding via intragastric tube for 14 days (subacute). The results showed that differences in SGOT level (p = 0.061), SGPT level (p = 0.82), and weight gain (p = 0.076) were not significant between the treatment and control groups, accompanied by the absence of clinical signs during the study. These indicate that subacute administration of chitosan-alginate coated microparticle of Garcinia mangostana Linn extract is safe until a dose of 2.0 gram/kgBW. Further studies are needed to evaluate the toxicity effects of this extract on other parameters and in a longer duration of exposure.

Original languageEnglish
Title of host publicationRecent Progress on
Subtitle of host publicationEnergy, Communities and Cities - Proceedings of International Symposium on Sustainable and Clean Energy, ISSCE 2019: Quality in Research 2019
EditorsYuliusman Yuliusman, Cindy Dianita
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735419896
DOIs
Publication statusPublished - 4 May 2020
Event16th International Conference on Quality in Research, QiR 2019 - 2019 International Symposium on Sustainable and Clean Energy, ISSCE 2019 - Padang, Indonesia
Duration: 22 Jul 201924 Jul 2019

Publication series

NameAIP Conference Proceedings
Volume2230
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference16th International Conference on Quality in Research, QiR 2019 - 2019 International Symposium on Sustainable and Clean Energy, ISSCE 2019
Country/TerritoryIndonesia
CityPadang
Period22/07/1924/07/19

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