Subacute oral toxicity test of chitosan-alginate coated microparticle of Garcinia mangostana Linn extract

Gede Bagus Yoga Satriadinatha, Siti Farida, Kamarza Mulia, Desak Gede Budi Krisnamurti

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Chitosan-alginate coated microparticle of Garcinia mangostana Linn extract promises an alternative treatment of colon cancer patients, as the component of Garcinia mangostana Linn extract has anticancer activity in colon cancer cell lines, and chitosan-alginate could deliver compound faster to colon and accelerate its absorption. However, there have not been any studies evaluating sub-acutely the toxicity effects of this compound on the liver (SGOT and SGPT) and clinical signs of toxicity. This study was conducted to evaluate the subacute toxicity effect of Chitosan-alginate coated microparticle of Garcinia mangostana Linn extract's oral administration. Fifty BALB/c mice were divided into five groups, including doses of 0.5 gram/kg, 1.0 gram/kg, 2.0 gram/kg, negative control, and normal group. Each rat was given an extract by force-feeding via intragastric tube for 14 days (subacute). The results showed that differences in SGOT level (p = 0.061), SGPT level (p = 0.82), and weight gain (p = 0.076) were not significant between the treatment and control groups, accompanied by the absence of clinical signs during the study. These indicate that subacute administration of chitosan-alginate coated microparticle of Garcinia mangostana Linn extract is safe until a dose of 2.0 gram/kgBW. Further studies are needed to evaluate the toxicity effects of this extract on other parameters and in a longer duration of exposure.

Original languageEnglish
Title of host publication4th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices
Subtitle of host publicationProceedings of the International Symposium of Biomedical Engineering, ISBE 2019
EditorsKenny Lischer, Tomy Abuzairi, Siti Fauziyah Rahman, Misri Gozan
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735419445
DOIs
Publication statusPublished - 10 Dec 2019
Event4th International Symposium of Biomedical Engineering�s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices, ISBE 2019 - Padang, West Sumatera, Indonesia
Duration: 22 Jul 201924 Jul 2019

Publication series

NameAIP Conference Proceedings
Volume2193
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference4th International Symposium of Biomedical Engineering�s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices, ISBE 2019
CountryIndonesia
CityPadang, West Sumatera
Period22/07/1924/07/19

Keywords

  • chitosan-alginate
  • Garcinia mangostana Linn
  • microparticle
  • subacute toxicity

Fingerprint Dive into the research topics of 'Subacute oral toxicity test of chitosan-alginate coated microparticle of Garcinia mangostana Linn extract'. Together they form a unique fingerprint.

  • Cite this

    Satriadinatha, G. B. Y., Farida, S., Mulia, K., & Krisnamurti, D. G. B. (2019). Subacute oral toxicity test of chitosan-alginate coated microparticle of Garcinia mangostana Linn extract. In K. Lischer, T. Abuzairi, S. F. Rahman, & M. Gozan (Eds.), 4th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices: Proceedings of the International Symposium of Biomedical Engineering, ISBE 2019 [020006] (AIP Conference Proceedings; Vol. 2193). American Institute of Physics Inc.. https://doi.org/10.1063/1.5139326