Study of population and covariate model in physiologically based pharmacokinetics model used for treatment planning in peptide receptor radionuclide therapy

Ade Riana, Supriyanto A. Pawiro, Deni Hardiansyah

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

In this study, we implemented for the first time the Population and Covariate Model (POPCOV) to simplify the Individual Treatment Planning (ITP) process in PRRT with minimal Physiologically based Pharmacokinetic (mPBPK) model. POPCOV method was used to predict the unknown parameters of the PBPK model using the individual covariates. Stepwise selection procedures (forward selection and backward elimination) were used for the covariate selection and the derivation of the final model. The performance of the final model was tested by comparing the predicted time-integrated activity coefficient (TIACs) from the Fixed-Dose Treatment Planning (FDP) i.e., mPBPK with mean parameters, and conventional ITP method, i.e., mPBPK with individual estimated parameters. Based on the POPCOV analysis, GFR was identified as the best covariate for the receptor density in the kidneys [Rk]. The final covariate model of receptor density in the kidney was: [Rk] (10-15mol/l) = 6.32x106∗(GFR/0.09)(0.67). These results indicated that the performance of POPCOV for ITP was around 12% better than the FDP and around 26% worse than the conventional ITP method for the kidneys. The results showed that the POPCOV method could be used as an alternative method in PRRT to predict kidneys TIACs in a case where the individual biokinetic data is unavailable.

Original languageEnglish
Title of host publication9th National Physics Seminar 2020
EditorsHadi Nasbey, Riser Fahdiran, Widyaningrum Indrasari, Esmar Budi, Fauzi Bakri, Teguh Budi Prayitno, Dewi Muliyati
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735440647
DOIs
Publication statusPublished - 2 Mar 2021
Event9th National Physics Seminar 2020 - Jakarta, Virtual, Indonesia
Duration: 20 Jun 2020 → …

Publication series

NameAIP Conference Proceedings
Volume2320
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference9th National Physics Seminar 2020
CountryIndonesia
CityJakarta, Virtual
Period20/06/20 → …

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