Study of gas voids using immunohistochemical response staining to CD68 post magnesium ECAP miniplate and screw implantation

Lisa Handayani, Sugeng Supriadi, Bambang Pontjo Priosoeryanto, Benny Syariefsyah Latief

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Nowadays various choices of material for fracture fixation and management are available, each with its own advantages and disadvantages. Magnesium ECAP has been gaining interest in biomaterial development researches due to its excellent mechanical properties and osteoanabolic effects towards bone metabolism. However, its corrosion rate cannot be disregarded. Immunohistochemical study can be conducted to identify responses from those processes indirectly by looking into traces of reaction in surrounding tissues. The purpose of this study is to evaluate the effect of gas voids from magnesium corrosion in microscopic preparation taken from rabbit's femur after being implanted with magnesium ECAP miniplate and screw by immunohistochemical staining in 1, 3, and 5 months interval for CD68 response. The results were calculated with histoscore and showed a decline on the fifth month. Immunohistochemical staining using CD68 have the ability to identify gas voids with high sensitivity and specificity, and gas voids formation post ECAP-treated magnesium miniplate and screw placement do not depend on its degradation rate.

Original languageEnglish
Title of host publication3rd Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices
Subtitle of host publicationProceedings of the International Symposium of Biomedical Engineering, ISBE 2018
EditorsPraswasti P.D.K. Wulan, Misri Gozan, Sotya Astutiningsih, Ghiska Ramahdita, Radon Dhelika, Prasetyanugraheni Kreshanti
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735418226
DOIs
Publication statusPublished - 9 Apr 2019
Event3rd International Symposium of Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2018 - Jakarta, Indonesia
Duration: 6 Aug 20188 Aug 2018

Publication series

NameAIP Conference Proceedings
Volume2092
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference3rd International Symposium of Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2018
CountryIndonesia
CityJakarta
Period6/08/188/08/18

Keywords

  • biodegradable
  • CD68
  • gas voids
  • immunohistochemistry
  • magnesium ECAP

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