TY - GEN
T1 - Study of gas voids using immunohistochemical response staining to CD68 post magnesium ECAP miniplate and screw implantation
AU - Handayani, Lisa
AU - Supriadi, Sugeng
AU - Priosoeryanto, Bambang Pontjo
AU - Latief, Benny Syariefsyah
N1 - Publisher Copyright:
© 2019 Author(s).
PY - 2019/4/9
Y1 - 2019/4/9
N2 - Nowadays various choices of material for fracture fixation and management are available, each with its own advantages and disadvantages. Magnesium ECAP has been gaining interest in biomaterial development researches due to its excellent mechanical properties and osteoanabolic effects towards bone metabolism. However, its corrosion rate cannot be disregarded. Immunohistochemical study can be conducted to identify responses from those processes indirectly by looking into traces of reaction in surrounding tissues. The purpose of this study is to evaluate the effect of gas voids from magnesium corrosion in microscopic preparation taken from rabbit's femur after being implanted with magnesium ECAP miniplate and screw by immunohistochemical staining in 1, 3, and 5 months interval for CD68 response. The results were calculated with histoscore and showed a decline on the fifth month. Immunohistochemical staining using CD68 have the ability to identify gas voids with high sensitivity and specificity, and gas voids formation post ECAP-treated magnesium miniplate and screw placement do not depend on its degradation rate.
AB - Nowadays various choices of material for fracture fixation and management are available, each with its own advantages and disadvantages. Magnesium ECAP has been gaining interest in biomaterial development researches due to its excellent mechanical properties and osteoanabolic effects towards bone metabolism. However, its corrosion rate cannot be disregarded. Immunohistochemical study can be conducted to identify responses from those processes indirectly by looking into traces of reaction in surrounding tissues. The purpose of this study is to evaluate the effect of gas voids from magnesium corrosion in microscopic preparation taken from rabbit's femur after being implanted with magnesium ECAP miniplate and screw by immunohistochemical staining in 1, 3, and 5 months interval for CD68 response. The results were calculated with histoscore and showed a decline on the fifth month. Immunohistochemical staining using CD68 have the ability to identify gas voids with high sensitivity and specificity, and gas voids formation post ECAP-treated magnesium miniplate and screw placement do not depend on its degradation rate.
KW - biodegradable
KW - CD68
KW - gas voids
KW - immunohistochemistry
KW - magnesium ECAP
UR - http://www.scopus.com/inward/record.url?scp=85064812112&partnerID=8YFLogxK
U2 - 10.1063/1.5096669
DO - 10.1063/1.5096669
M3 - Conference contribution
AN - SCOPUS:85064812112
T3 - AIP Conference Proceedings
BT - 3rd Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices
A2 - Wulan, Praswasti P.D.K.
A2 - Gozan, Misri
A2 - Astutiningsih, Sotya
A2 - Ramahdita, Ghiska
A2 - Dhelika, Radon
A2 - Kreshanti, Prasetyanugraheni
PB - American Institute of Physics Inc.
T2 - 3rd International Symposium of Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, and Medical Devices, ISBE 2018
Y2 - 6 August 2018 through 8 August 2018
ER -