AgNOR and MIB-1 are marker for breast cancer cell proliferation and can be use as based for radiotherapy treatment after surgery. Value of AgNOR and MIB-1 index were determined using staining and immunohistochemistry staining method respectively from 25 of microscopic slides of breast cancer tissue patients with surgery, and grouped based on degree of differentiation, 3 slides were good degree (G1), 16 slides were medium degree (G2) and 6 slides were poor degree (between G2 and G3). The result shown that the value of AgNOR and MIB-1 index were tended to increase with the increased differentiation degree. There was a positive correlation between the value of AgNOR and index of MIB-1 in all group of differentiation degree (r = 0.21), there is a negative correlation between AgNOR and MIB-1 on G1 (r =-0,97), positive correlation in G2 (r = 0.36) as well as positive correlation between G2 and G3 (r = 0.33). The positive correlation between AgNOR and MIB-1 were associated to the increased of G1, S and G2 phase in the proliferation cell and an increase of cells undergoing mitosis. The negative correlation were caused by the different cell proportion in G1, S and G2 phase, and undergoing mitotis.
|Journal||Indonesian Journal of Clinical Pharmacy|
|Publication status||Published - 2012|