Structure activity relationship analysis of antioxidant activity of simple benzene carboxylic acids group, based on multiple linear regression

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2 Citations (Scopus)

Abstract

A multivariate analysis of the quantitative relationship of antioxidant structure and activity of a series of benzoic acid derivatives based on computational chemical properties was calculated. The parameters were obtained from the optimized structure of ionization pKa and hydrophobic ClogP while the compound activity was obtained from the literature. Analysis of the relationship between antioxidant activity and chemical properties of the compound was performed with the SPSS 21 program. The analysis result gives the best equation model as follows: Log 1 / IC50 = -1.514 + 0,516 log P + 0.087 pKa (n = 10 r = 0,962 SE = 0,301 Fcalc./Ftable = 1,422).

Original languageEnglish
Pages (from-to)2656-2660
Number of pages5
JournalOriental Journal of Chemistry
Volume34
Issue number5
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • Antioxidant
  • Benzoic acid derivatives
  • QSAR

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