Structural Design and Synthesis of Novel Cyclic Peptide Inhibitors Targeting Mycobacterium tuberculosis Transcription

Keyphrases

• Rifampicin 100%
• Mycobacterium Tuberculosis (M. tb) 100%
• Structural Design 100%
• Structural Synthesis 100%
• Cyclic Peptoids 100%
• Cyclic Peptide 80%
• Drug Resistance Tuberculosis 60%
• RpoB 40%
• Antitubercular Agents 40%
• Transcription Initiation 40%
• Tuberculosis 20%
• Synthesis Methods 20%
• Drug Interactions 20%
• Infectious Diseases 20%
• Structural Modification 20%
• 1H nuclear Magnetic Resonance (1H NMR) 20%
• Virtual Screening 20%
• Electrospray Ionization Mass Spectrometry 20%
• Acetylation 20%
• Amidation 20%
• Binding Site 20%
• Tuberculosis Drugs 20%
• C-terminus 20%
• Clinical Profile 20%
• RNA-dependent RNA Polymerase (RdRP) 20%
• Molecular Simulation 20%
• RNA Polymerase Subunits 20%
• Plasma Instabilities 20%
• Linear Peptide 20%
• Fmoc Chemistry 20%
• Tuberculosis RNA 20%
• Analytical HPLC 20%
• Solid-phase Peptide Synthesis 20%
• Long RNAs 20%
• Target RNA 20%
• N-terminus 20%

Biochemistry, Genetics and Molecular Biology

• Mycobacterium Tuberculosis 100%
• Transcription 100%
• Cyclic Peptide 100%
• Drug Resistance 60%
• RNA Polymerase 40%
• Transcription Initiation 40%
• Binding Site 20%
• RNA 20%
• High-Performance Liquid Chromatography 20%
• N-Terminus 20%
• C-Terminus 20%
• Acetylation 20%
• Peptide Synthesis 20%
• Electrospray Mass Spectrometry 20%
• Amidation 20%
• Blood Plasma 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Mycobacterium Tuberculosis 100%
• Rifampicin 100%
• Cyclopeptide 100%
• Drug Resistance 60%
• Side Effect 40%
• RNA Polymerase 40%
• Diseases 40%
• Binding Site 20%
• High Performance Liquid Chromatography 20%
• Bioavailability 20%
• Virtual Screening 20%