Strategies for the use of Ginkgo biloba extract, EGb 761®, in the treatment and management of mild cognitive impairment in Asia: Expert consensus

Nagaendran Kandiah, Yee Fai Chan, Christopher Chen, Darwin Dasig, Jacqueline Dominguez, Seol Heui Han, Jianping Jia, Sang Yun Kim, Panita Limpawattana, Li Ling Ng, Dinh Toan Nguyen, Paulus Anam Ong, Encarnita Raya-Ampil, Nor'izzati Saedon, Vorapun Senanarong, Siti Setiati, Harjot Singh, Chuthamanee Suthisisang, Tong Mai Trang, Yuda TuranaNarayanaswamy Venketasubramanian, Fee Mann Yong, Yong Chul Youn, Ralf Ihl

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


Background: Mild cognitive impairment (MCI) is a neurocognitive state between normal cognitive aging and dementia, with evidence of neuropsychological changes but insufficient functional decline to warrant a diagnosis of dementia. Individuals with MCI are at increased risk for progression to dementia; and an appreciable proportion display neuropsychiatric symptoms (NPS), also a known risk factor for dementia. Cerebrovascular disease (CVD) is thought to be an underdiagnosed contributor to MCI/dementia. The Ginkgo biloba extract, EGb 761®, is increasingly being used for the symptomatic treatment of cognitive disorders with/without CVD, due to its known neuroprotective effects and cerebrovascular benefits. Aims: To present consensus opinion from the ASian Clinical Expert group on Neurocognitive Disorders (ASCEND) regarding the role of EGb 761® in MCI. Materials & Methods: The ASCEND Group reconvened in September 2019 to present and critically assess the current evidence on the general management of MCI, including the efficacy and safety of EGb 761® as a treatment option. Results: EGb 761® has demonstrated symptomatic improvement in at least four randomized trials, in terms of cognitive performance, memory, recall and recognition, attention and concentration, anxiety, and NPS. There is also evidence that EGb 761® may help delay progression from MCI to dementia in some individuals. Discussion: EGb 761® is currently recommended in multiple guidelines for the symptomatic treatment of MCI. Due to its beneficial effects on cerebrovascular blood flow, it is reasonable to expect that EGb 761® may benefit MCI patients with underlying CVD. Conclusion: As an expert group, we suggest it is clinically appropriate to incorporate EGb 761® as part of the multidomain intervention for MCI.

Original languageEnglish
Pages (from-to)149-162
Number of pages14
JournalCNS Neuroscience and Therapeutics
Issue number2
Publication statusPublished - 17 Feb 2021


  • cerebrovascular disease
  • dementia
  • EGb 761
  • Ginkgo biloba
  • mild cognitive impairment
  • neuropsychiatric symptoms


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