TY - JOUR
T1 - Stone recurrence among Indonesian kidney stone formers
T2 - a comprehensive analysis of genetic polymorphism, demographic, and clinical factors
AU - Atmoko, Widi
AU - Savira, Missy
AU - Fajriani, Rosalina
AU - Wistara, Sevita Sathya
AU - Asmarinah,
AU - Harahap, Alida Roswita
AU - Witjaksono, Fiastuti
AU - Werdhani, Retno Asti
AU - Safriadi, Ferry
AU - Hamid, Agus Rizal Ardy Hariandy
AU - Birowo, Ponco
AU - Rasyid, Nur
AU - Taher, Akmal
N1 - Publisher Copyright:
© 2024, Faculty of Medicine, Universitas Indonesia. All rights reserved.
PY - 2024/9
Y1 - 2024/9
N2 - BACKGROUND The recurrence rate of kidney stone disease (KSD) can exceed 50% within 5 years. This study aimed to investigate factors associated with stone recurrence based on single nucleotide polymorphisms (SNPs) of the calcium-sensing receptor (CaSR) rs1801725 and rs1042636, demographic, and clinical profiles. METHODS We collected data on the demographic and clinical characteristics of 80 adult kidney stone formers from April 2021 to September 2022, including peripheral blood samples, morning and 24-hour urine, and 7-day water intake records. Real-time polymerase chain reaction was used to evaluate SNP. Comparisons were made between patients with recurrent and first-time stones. RESULTS 41% of 80 patients have experienced stone recurrence. Recurrent stone formers exhibited significantly higher 24-hour urine calcium excretion (p = 0.03) and lower serum calcium levels (p = 0.019) than first-time stone formers. Hypocitraturia (100%), low urine volume (78%), and hyperoxaluria (55%) were the main abnormalities of all patients. No significant differences were found in CaSR gene polymorphisms and other demographic, biochemical, or clinical parameters. CONCLUSIONS Recurrent stone formers had higher 24-hour urine calcium excretion and lower serum calcium levels. Other risk factors and CaSR polymorphisms may insignificantly affect KSD recurrence.
AB - BACKGROUND The recurrence rate of kidney stone disease (KSD) can exceed 50% within 5 years. This study aimed to investigate factors associated with stone recurrence based on single nucleotide polymorphisms (SNPs) of the calcium-sensing receptor (CaSR) rs1801725 and rs1042636, demographic, and clinical profiles. METHODS We collected data on the demographic and clinical characteristics of 80 adult kidney stone formers from April 2021 to September 2022, including peripheral blood samples, morning and 24-hour urine, and 7-day water intake records. Real-time polymerase chain reaction was used to evaluate SNP. Comparisons were made between patients with recurrent and first-time stones. RESULTS 41% of 80 patients have experienced stone recurrence. Recurrent stone formers exhibited significantly higher 24-hour urine calcium excretion (p = 0.03) and lower serum calcium levels (p = 0.019) than first-time stone formers. Hypocitraturia (100%), low urine volume (78%), and hyperoxaluria (55%) were the main abnormalities of all patients. No significant differences were found in CaSR gene polymorphisms and other demographic, biochemical, or clinical parameters. CONCLUSIONS Recurrent stone formers had higher 24-hour urine calcium excretion and lower serum calcium levels. Other risk factors and CaSR polymorphisms may insignificantly affect KSD recurrence.
KW - genetic polymorphism
KW - Indonesia
KW - kidney stone
KW - metabolic
KW - recurrence
UR - http://www.scopus.com/inward/record.url?scp=85211582593&partnerID=8YFLogxK
U2 - 10.13181/mji.oa.247596
DO - 10.13181/mji.oa.247596
M3 - Article
AN - SCOPUS:85211582593
SN - 0853-1773
VL - 33
SP - 190
EP - 197
JO - Medical Journal of Indonesia
JF - Medical Journal of Indonesia
IS - 3
ER -