TY - JOUR
T1 - Stemness markers in hepatocellular carcinoma of Eastern vs. Western population
T2 - Etiology matters?
AU - Sukowati, Caecilia HC
AU - El-Khobar, Korri
AU - Jasirwan, Chyntia Olivia Maurine
AU - Kurniawan, Juferdy
AU - Gani, Rino Alvani
N1 - Funding Information:
CHCS is supported by 2022-2023 grant of the Fondazione Umberto Veronesi, Milan, Italy. KEEK received a fellowship of the Ministero degli Affari Esteri e della Cooperazione Internazionale (MAECI) of Italy for the Progetto Co-Tutela at the FIF.
Publisher Copyright:
© 2023 Fundación Clínica Médica Sur, A.C.
PY - 2024/1/1
Y1 - 2024/1/1
N2 - Hepatocellular carcinoma (HCC) is one of the most common cancers with a high mortality rate. HCC development is associated with its underlying etiologies, mostly caused by infection of chronic hepatitis B virus (HBV) and hepatitis C virus (HCV), alcohol, non-alcoholic fatty liver disease, and exposure to aflatoxins. These variables, together with human genetic susceptibility, contribute to HCC molecular heterogeneity, including at the cellular level. HCC initiation, tumor recurrence, and drug resistance rates have been attributed to the presence of liver cancer stem cells (CSC). This review summarizes available data regarding whether various HCC etiologies may be associated to the appearance of CSC biomarkers. It also described the genetic variations of tumoral tissues obtained from Western and Eastern populations, in particular to the oncogenic effect of HBV in the human genome.
AB - Hepatocellular carcinoma (HCC) is one of the most common cancers with a high mortality rate. HCC development is associated with its underlying etiologies, mostly caused by infection of chronic hepatitis B virus (HBV) and hepatitis C virus (HCV), alcohol, non-alcoholic fatty liver disease, and exposure to aflatoxins. These variables, together with human genetic susceptibility, contribute to HCC molecular heterogeneity, including at the cellular level. HCC initiation, tumor recurrence, and drug resistance rates have been attributed to the presence of liver cancer stem cells (CSC). This review summarizes available data regarding whether various HCC etiologies may be associated to the appearance of CSC biomarkers. It also described the genetic variations of tumoral tissues obtained from Western and Eastern populations, in particular to the oncogenic effect of HBV in the human genome.
KW - Biomarkers
KW - Cancer stem cells
KW - Etiology
KW - Hepatocellular carcinoma
KW - Stem cells
UR - http://www.scopus.com/inward/record.url?scp=85173150306&partnerID=8YFLogxK
U2 - 10.1016/j.aohep.2023.101153
DO - 10.1016/j.aohep.2023.101153
M3 - Review article
C2 - 37734662
AN - SCOPUS:85173150306
SN - 1665-2681
VL - 29
JO - Annals of Hepatology
JF - Annals of Hepatology
IS - 1
M1 - 101153
ER -