Statin Administration for Primary Prevention of Cardiovascular Complication Among Type 2 Diabetic Patients with Good Lipid Profile: Evidence Based Report

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Abstract

One of the most fatal complications in diabetic patients is diabetic heart disease. Dyslipidemia becomes one of many risk factors that contribute to the occurrence of cardiovascular complication among diabetic patients. Some studies showed the effectiveness of statin in improving lipid profile among type 2 diabetic patients with dyslipidemia, which finally reduce the occurrence of cardiovascular complication. This report aims to identify whether statin is effective in preventing cardiovascular complication among diabetic patients with normal lipid profile. A search was conducted on PubMed and Google. After the selection of title and abstract was done using inclusion and exclusion criteria. Eleven original articles were found, but only three studies were used. All selected studies were critically appraised for its validity, importance and applicability.All three studies showed the reduction in cardiovascular complication and mortality related to cardiovascular. The relative risk reduction ranged from 18-37.5%. The absolute risk reduction ranged from 1.9%-3% and number needed to treat ranged from 33-53. Beside the reduction in cardiovascular complication, statin therapy was also proven to decrease the occurrence of cerebrovascular complication among type 2 diabetic patients. The administration of statin is effective in reducing the risk of cardiovascular complication among type 2 diabetic patients with normal lipid profile.
Original languageEnglish
JournalJournal of the Indonesian Medical Association
Publication statusPublished - 2011

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