Sperm Na+ K+-ATPase and Ca2+-ATPase activities: A potential predictive parameter of sperm motility disorder in infertile men

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Current highlight on the etiology of male infertility is disorder of sperm motility in which caused by ion homeostasis imbalance involving the ubiquitous multifunctional transmembrane protein, Na+K+-ATPase and Ca2+-ATPase enzymes. The emphasis of this review is evaluating the sperm Na+K+-ATPase and Ca2+ATPase activity as predictive parameters of sperm motility disorder. To this purpose, a computerized search of PubMed database was performed and obtained data were reviewed in this paper. The retrieved studies were laboratory experiments involving human and mice sperm as the subjects. Na+ K+-ATPase and Ca2+-ATPase play an essential role in sperm motility by controlling ion homeostasis. Na+ K+-ATPase maintains the intracellular pH by transporting 3 Na+ out and 2 K+ into the cell, whereas Ca2+-ATPase extrudes Ca2+ from the cell. The impairment of these enzymes and its isoforms, Na+ K+-ATPase a4 and PMCA4 expression were proved to decrease sperm motility.

Original languageEnglish
Pages (from-to)411-416
Number of pages6
JournalBiomedical and Pharmacology Journal
Volume11
Issue number1
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • Ca2+ATPase
  • Male infertility
  • Na+ K+-ATPase
  • Sperm motility

Fingerprint Dive into the research topics of 'Sperm Na<sup>+</sup> K<sup>+</sup>-ATPase and Ca<sup>2+</sup>-ATPase activities: A potential predictive parameter of sperm motility disorder in infertile men'. Together they form a unique fingerprint.

Cite this