TY - JOUR
T1 - Specific markers for hepatic progenitor cells
AU - Adnindya, Msy Rulan
AU - Indriyani,
AU - Nasution, Ahmad Azmi
AU - Liem, Isabella Kurnia
N1 - Publisher Copyright:
© 2017 Msy Rulan Adnindya, Indriyani, Ahmad Azmi Nasution and Isabella Kurnia Liem.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - One of mammalian organs that has remarkable ability to regenerate, liver, regenerates through the proliferation of hepatocytes or proliferation and differentiation of the stem cells resident. Some literatures states that these stem cells, the Hepatic Progenitor Cells (HPCs), are oval cells that have bipotential ability to be cholangiocytes and hepatocytes. However, the mechanisms of programming, activation of proliferation and maturation/differentiation have not completely understood. There are still disagreements on the sources and characterictics of HPCs. Consequently, these lead to a question on the characteristic (specific marker) of HPCs. To summarize the specific markers for HPCs that have ever been identified, the writers did a systematic review on 12 papers that fulfilled the research criteria and concluded that the markers used to identify HPCs are a combination of classic HPCs markers, i.e., oval cells (OV6 andOC2) progenitor/immature cells (CD56, Oct-3/4, DLK1, EFNA1 and Chrom-A), hepatocytes and cholangiocytes marker (Alb, AFP, CK7, CK8, CK18, CK19, GGT, EpCAM, CD24 and CD44) and hematopoietic stem cells markers (CD34, CD45, CD109, CD133, c-kit and Thy-1) since HPCs may share similar lineage as hematopoietic stem cells, hepatocytes and cholangiocytes. Precise markers for HPCs could not yet be determined; therefore, several markers should be combined to identify the HPCs. Difficulties in finding precise markers for HPCs might be caused by different expression of markers based on the HPCs differentiation and maturity.
AB - One of mammalian organs that has remarkable ability to regenerate, liver, regenerates through the proliferation of hepatocytes or proliferation and differentiation of the stem cells resident. Some literatures states that these stem cells, the Hepatic Progenitor Cells (HPCs), are oval cells that have bipotential ability to be cholangiocytes and hepatocytes. However, the mechanisms of programming, activation of proliferation and maturation/differentiation have not completely understood. There are still disagreements on the sources and characterictics of HPCs. Consequently, these lead to a question on the characteristic (specific marker) of HPCs. To summarize the specific markers for HPCs that have ever been identified, the writers did a systematic review on 12 papers that fulfilled the research criteria and concluded that the markers used to identify HPCs are a combination of classic HPCs markers, i.e., oval cells (OV6 andOC2) progenitor/immature cells (CD56, Oct-3/4, DLK1, EFNA1 and Chrom-A), hepatocytes and cholangiocytes marker (Alb, AFP, CK7, CK8, CK18, CK19, GGT, EpCAM, CD24 and CD44) and hematopoietic stem cells markers (CD34, CD45, CD109, CD133, c-kit and Thy-1) since HPCs may share similar lineage as hematopoietic stem cells, hepatocytes and cholangiocytes. Precise markers for HPCs could not yet be determined; therefore, several markers should be combined to identify the HPCs. Difficulties in finding precise markers for HPCs might be caused by different expression of markers based on the HPCs differentiation and maturity.
KW - Cholangiocyte
KW - Hepatic progenitor cells
KW - Hepatic progenitor cells marker
KW - Hepatoblast
KW - Hepatocyte
KW - Oval cells
UR - http://www.scopus.com/inward/record.url?scp=85030674227&partnerID=8YFLogxK
U2 - 10.3844/ojbsci.2017.187.192
DO - 10.3844/ojbsci.2017.187.192
M3 - Review article
AN - SCOPUS:85030674227
SN - 1608-4217
VL - 17
SP - 187
EP - 192
JO - OnLine Journal of Biological Sciences
JF - OnLine Journal of Biological Sciences
IS - 3
ER -