TY - JOUR
T1 - Spatiotemporal heterogeneity of zika virus transmission in indonesia
T2 - Serosurveillance data from a pediatric population
AU - Sasmono, R. Tedjo
AU - Johar, Edison
AU - Yohan, Benediktus
AU - Ma'Roef, Chairin Nisa
AU - Pronyk, Paul
AU - Hadinegoro, Sri Rezeki
AU - Soepardi, Elizabeth Jane
AU - Bouckenooghe, Alain
AU - Hawley, William A.
AU - Rosenberg, Ronald
AU - Powers, Ann M.
AU - Soebandrio, Amin
AU - Myint, Khin Saw Aye
N1 - Funding Information:
Financial support: This work was supported by the Ministry of Research, Technology, and Higher Education of the Republic of Indonesia, the United Nations Children’s Fund, and the U.S. Centers for Disease Control and Prevention.
Publisher Copyright:
© 2021 by The American Society of Tropical Medicine and Hygiene.
PY - 2021/6
Y1 - 2021/6
N2 - The presence of Zika virus (ZIKV) in Indonesia has been recognized since the 1970s, but its transmission dynamics there have been poorly understood. To understand more fully the geographic distribution and burden of ZIKV infection, we performed retrospective serological tests on specimens collected from asymptomatic children age 5 to 9 years old living at 30 sites in 14 provinces. Of 870 serum samples tested, 9.2% were found to be positive for anti-ZIKV antibodies, as confirmed by plaque reduction neutralization assays. This was the same overall prevalence reported previously for 1- to 4-year-old children collected at the same sites at the same time. Together with geographic differences in seroprevalence between the age groups, these data suggest that, although ZIKV might be endemic in Indonesia, its occurrence has been focal and episodic.
AB - The presence of Zika virus (ZIKV) in Indonesia has been recognized since the 1970s, but its transmission dynamics there have been poorly understood. To understand more fully the geographic distribution and burden of ZIKV infection, we performed retrospective serological tests on specimens collected from asymptomatic children age 5 to 9 years old living at 30 sites in 14 provinces. Of 870 serum samples tested, 9.2% were found to be positive for anti-ZIKV antibodies, as confirmed by plaque reduction neutralization assays. This was the same overall prevalence reported previously for 1- to 4-year-old children collected at the same sites at the same time. Together with geographic differences in seroprevalence between the age groups, these data suggest that, although ZIKV might be endemic in Indonesia, its occurrence has been focal and episodic.
UR - http://www.scopus.com/inward/record.url?scp=85107590950&partnerID=8YFLogxK
U2 - 10.4269/ajtmh.21-0010
DO - 10.4269/ajtmh.21-0010
M3 - Article
C2 - 33939632
AN - SCOPUS:85107590950
SN - 0002-9637
VL - 104
SP - 2220
EP - 2223
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
IS - 6
ER -
