Solvent extraction of polyhydroxybutyrate with NaClO from Spirulina platensis for capsule ingredients

Dianursanti, Kanya C.H. Alifia, Putri R. Sari

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

It is predicted in 2019, 91.1% of capsule shells produced are made from gelatin which is not suitable for vegetarians and some religious groups. Research on vegetable capsule shells began to develop to substitute gelatin using seaweed extracts such as carrageenan, alginate, HPMC, and polyhydroxybutyrate. Spirulina platensis microalgae is a PHB producer that is easy to cultivate, and its production can be optimised by modifying the extraction method. Solvent extraction is the most simple and economical extraction method with general stages in the form of cell disruption, PHB precipitation, and PHB purification. Sodium hypochlorite (NaClO) is a cell-disrupting solvent that is widely used for the extraction of PHB from microalgae. The parameters tested in this study consist of concentration of S. platensis sample cells shown as optical density (OD) ranging from 1, 2, 3, 4, 5, and 6. The PHB quantification and characterization method used was FTIR, and it showed the similarity between extracted PHB from Spirulina platensis with commercial PHB. The expected results of this PHB extraction are to get the maximum yield of PHB and the most efficient extraction method based on the independent variables. Extraction of microalgae sample with OD 4 using 4% NaClO is expected to have the highest yield of PHB.

Original languageEnglish
Title of host publication4th Biomedical Engineering''s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices
Subtitle of host publicationProceedings of the International Symposium of Biomedical Engineering, ISBE 2019
EditorsKenny Lischer, Tomy Abuzairi, Siti Fauziyah Rahman, Misri Gozan
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735419445
DOIs
Publication statusPublished - 10 Dec 2019
Event4th International Symposium of Biomedical Engineering�s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices, ISBE 2019 - Padang, West Sumatera, Indonesia
Duration: 22 Jul 201924 Jul 2019

Publication series

NameAIP Conference Proceedings
Volume2193
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference4th International Symposium of Biomedical Engineering�s Recent Progress in Biomaterials, Drugs Development, Health, and Medical Devices, ISBE 2019
CountryIndonesia
CityPadang, West Sumatera
Period22/07/1924/07/19

Keywords

  • NaClO
  • NaOH
  • polyhydroxybutyrate
  • solvent extraction
  • Spirulina platensis

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