@inproceedings{4f7bca10f90b4d29b2f31939ef200148,
title = "Solubilization of gliclazide in microemulsion stabilized using saponin-based surfactants from leaf extract of Orthosiphonaristatus (Blume) Miq",
abstract = "Gliclazide is an antidiabetic drug that has a low solubility in water, so it has low bioavailability. To improve the gliclazide solubility in water, oil in water (o/w) microemulsion system is used. In this study, solubilization of gliclazide in microemulsion that emulsified using saponin-based surfactants from leaf extract of Orthosiphonaristatus (Blume) Miq has been investigated. The oil phase used is palm oil. The preparation of microemulsion was conducted by titration method with various ratios of surfactant and co-surfactant, and ratios of oil with surfactant and co-surfactant mixture. The stability of microemulsion was observed using turbidimeter, microscope, and particle size analyzer (PSA). Solubilization of gliclazide was observed by UV-Vis spectrophotometer and FTIR spectroscopy. The optimum condition of microemulsion formation was resulted in the ratio of surfactant to co-surfactant (Sm) at 8:2, and ratio of surfactant and co-surfactant mixture (Sm) to oil at 10:1. Size distribution of microemulsion particle was confirmed as 10.92 nm, and microemulsion size after gliclazide addition as 91.21 nm using PSA. The optimum result of gliclazide solubility in o/w microemulsion was obtained at 1.6 mg/mL.",
keywords = "Microemulsion, Orthosiphonaristatus (Blume) Miq, gliclazide, saponin-based surfactants, solubilization",
author = "M. Abbas and N. Sari and T. Utari and Y. Yulizar and Apriandanu, {D. O.B.}",
note = "Publisher Copyright: {\textcopyright} 2018 Author(s).; 3rd International Symposium on Current Progress in Mathematics and Sciences 2017, ISCPMS 2017 ; Conference date: 26-07-2017 Through 27-07-2017",
year = "2018",
month = oct,
day = "22",
doi = "10.1063/1.5064097",
language = "English",
series = "AIP Conference Proceedings",
publisher = "American Institute of Physics Inc.",
editor = "Ratna Yuniati and Terry Mart and Anggraningrum, {Ivandini T.} and Djoko Triyono and Sugeng, {Kiki A.}",
booktitle = "Proceedings of the 3rd International Symposium on Current Progress in Mathematics and Sciences 2017, ISCPMS 2017",
address = "United States",
}