Solubilization of gliclazide in microemulsion stabilized using saponin-based surfactants from leaf extract of Orthosiphonaristatus (Blume) Miq

M. Abbas, N. Sari, Tresye Utari, Yoki Yulizar, D. O.B. Apriandanu

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

3 Citations (Scopus)

Abstract

Gliclazide is an antidiabetic drug that has a low solubility in water, so it has low bioavailability. To improve the gliclazide solubility in water, oil in water (o/w) microemulsion system is used. In this study, solubilization of gliclazide in microemulsion that emulsified using saponin-based surfactants from leaf extract of Orthosiphonaristatus (Blume) Miq has been investigated. The oil phase used is palm oil. The preparation of microemulsion was conducted by titration method with various ratios of surfactant and co-surfactant, and ratios of oil with surfactant and co-surfactant mixture. The stability of microemulsion was observed using turbidimeter, microscope, and particle size analyzer (PSA). Solubilization of gliclazide was observed by UV-Vis spectrophotometer and FTIR spectroscopy. The optimum condition of microemulsion formation was resulted in the ratio of surfactant to co-surfactant (Sm) at 8:2, and ratio of surfactant and co-surfactant mixture (Sm) to oil at 10:1. Size distribution of microemulsion particle was confirmed as 10.92 nm, and microemulsion size after gliclazide addition as 91.21 nm using PSA. The optimum result of gliclazide solubility in o/w microemulsion was obtained at 1.6 mg/mL.

Original languageEnglish
Title of host publicationProceedings of the 3rd International Symposium on Current Progress in Mathematics and Sciences 2017, ISCPMS 2017
EditorsRatna Yuniati, Terry Mart, Ivandini T. Anggraningrum, Djoko Triyono, Kiki A. Sugeng
PublisherAmerican Institute of Physics Inc.
ISBN (Electronic)9780735417410
DOIs
Publication statusPublished - 22 Oct 2018
Event3rd International Symposium on Current Progress in Mathematics and Sciences 2017, ISCPMS 2017 - Bali, Indonesia
Duration: 26 Jul 201727 Jul 2017

Publication series

NameAIP Conference Proceedings
Volume2023
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Conference

Conference3rd International Symposium on Current Progress in Mathematics and Sciences 2017, ISCPMS 2017
Country/TerritoryIndonesia
CityBali
Period26/07/1727/07/17

Keywords

  • Microemulsion
  • Orthosiphonaristatus (Blume) Miq
  • gliclazide
  • saponin-based surfactants
  • solubilization

Fingerprint

Dive into the research topics of 'Solubilization of gliclazide in microemulsion stabilized using saponin-based surfactants from leaf extract of Orthosiphonaristatus (Blume) Miq'. Together they form a unique fingerprint.

Cite this