Sinonasal lymphomas in Indonesia: Immunophenotype and Epstein-Barr virus association

Endang S.R. Hardjolukito, Antonius Nikolas Kurniawan, Ria Kodariah, Maria Francisca Ham, Wen Juan Luo, Shin Ichi Nakatsuka, Katsuyuki Aozasa

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Sinonasal lymphoma is a rare disease with NK/T-cell (NKTC) or B-cell immunophenotype. Previous study revealed the geographic difference in frequency of NKTC lymphoma (NKTCL) and almost constant association with Epstein-Barr virus (EBV) infection. Through review of 41 cases with sinonasal lymphoproliferative diseases registered in the Department of Anatomical Pathology, University of Indonesia during the period 1994 to 2002, thirty-five were accepted as sinonasal lymphoma. Immunohistochemistry revealed that 20 cases (57%) were NK/T-cell type and 15 (43%) B-cell type with large cell morphology, i.e.,diffuse large B-cell lymphoma. NKTCL showed a marked male preponderance (M/F= 4: 1) and younger onset of disease (median age, 37 years), and B-cell lymphoma showed a relative female preponderance (1: 1.5) and older disease onset (median age, 49 years). In situ hybridization using EBER-1 probe revealed that 90 % of NKTCL were EBV-positive, but none of B-cell lymphoma were EBV-positive. This is the first report on sinonasal lymphoma in Indonesia showing relative predominance of B-cell lymphoma compared to other Asian countries and Peru (14-24 %). Lack of EBV-association in Indonesian sinonasal B-cell lymphoma showed a marked contrast to that in other Asian countries (EBV positive rate, 25-41 %). Predominance of sinonasal B-cell lymphoma without EBV genome might suggest presence of specific etiologic factors in Indonesia.

Original languageEnglish
Pages (from-to)71-76
Number of pages6
JournalMedical Journal of Indonesia
Volume13
Issue number2
DOIs
Publication statusPublished - 1 Apr 2004

Keywords

  • B-cell
  • Epstein-barr virus
  • Indonesia
  • NK/T-cell
  • Sinonasal lymphoma

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