Silicasupported copper(II) oxide for the synthesis of curcumin derivatives containing pyrazole and isoxazole scaffolds

Antonius Herry Cahyana, Bayu Ardiansah, Wahyu Hidayat Ibrahim

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Preparation of CuO/SiO 2 catalyst has been done via sol-gel method using copper nitrate solution and TEOS as precursors. Several instruments such as FT-IR, SEM, EDAX, XRD and particle sizer were employed to characterize the obtained material. Then, CuO/SiO 2 catalyst was successfullyusedin the synthesis of three curcumin derivatives, 4,4'-((1E,1‘E)-(1H-pyrazole-3,5-diyl)bis(ethene-2,1-diyl))bis(2-methoxyphenol) (Compound 1), 4,4'-((1E,1‘E)-(1- phenyl-1H-pyrazole-3,5-diyl)bis(ethene-2,1-diyl))bis(2-methoxyphenol) (Compound 2) and 4,4'-((1E,1‘E)- (isoxazole-3,5-diylbis(ethene-2,1-diyl))bis(2-methoxyphenol) (Compound 3) with good yields.

Original languageEnglish
Pages (from-to)471-477
Number of pages7
JournalRasayan Journal of Chemistry
Volume12
Issue number2
DOIs
Publication statusPublished - 1 Apr 2019

Keywords

  • Curcumin
  • Heterogeneous catalyst
  • Isoxazole
  • Pyrazole

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