TY - JOUR
T1 - Significance of aldehyde dehydrogenase 1 expression in stromal cells of diffuse large B-cell lymphoma
AU - Fujita, Shigeki
AU - Morii, Eiichi
AU - Rahadiani, Nur
AU - Wada, Naoki
AU - Hori, Yumiko
AU - Ikeda, Jun Ichiro
AU - Aozasa, Katsuyuki
PY - 2011/7/1
Y1 - 2011/7/1
N2 - Aldehyde dehydrogenase (ALDH) 1 is expressed in various stem/progenitor cells, including cancer-initiating cells (CICs). In the present study, ALDH1 expression was immuno-histochemically examined in diffuse large B-cell lymphoma (DLBCL). Unexpectedly, ALDH1 expression was occasionally detected in stromal cells, but not in lymphoma cells. Positively stained cells were CD68+ cells with voluminous cytoplasm and fascin+ cells with reticular morphology, designated as macrophages and dendritic cells (DCs), respectively. The presence of ALDH1+ macrophages was not correlated with stage, response to therapies and prognosis. However, cases with ALDH1+ DCs were mostly nodal, which showed a poorer response to therapies and a worse overall survival rate than cases without ALDH1+ DCs. The presence of ALDH1+ DCs appears to be involved in the malignant potential of DLBCL in lymph node.
AB - Aldehyde dehydrogenase (ALDH) 1 is expressed in various stem/progenitor cells, including cancer-initiating cells (CICs). In the present study, ALDH1 expression was immuno-histochemically examined in diffuse large B-cell lymphoma (DLBCL). Unexpectedly, ALDH1 expression was occasionally detected in stromal cells, but not in lymphoma cells. Positively stained cells were CD68+ cells with voluminous cytoplasm and fascin+ cells with reticular morphology, designated as macrophages and dendritic cells (DCs), respectively. The presence of ALDH1+ macrophages was not correlated with stage, response to therapies and prognosis. However, cases with ALDH1+ DCs were mostly nodal, which showed a poorer response to therapies and a worse overall survival rate than cases without ALDH1+ DCs. The presence of ALDH1+ DCs appears to be involved in the malignant potential of DLBCL in lymph node.
KW - Aldehyde dehydrogenase 1
KW - Dendritic cells
KW - Diffuse large B cell lymphoma
KW - Macrophages
KW - Prognosis
KW - Stroma
UR - http://www.scopus.com/inward/record.url?scp=79958064121&partnerID=8YFLogxK
U2 - 10.3892/etm.2011.269
DO - 10.3892/etm.2011.269
M3 - Article
AN - SCOPUS:79958064121
SN - 1792-0981
VL - 2
SP - 591
EP - 594
JO - Experimental and Therapeutic Medicine
JF - Experimental and Therapeutic Medicine
IS - 4
ER -
