TY - JOUR
T1 - Shining the light on mesenchymal stem cell-derived exosomes in breast cancer
AU - Al-Awsi, Ghaidaa Raheem Lateef
AU - Alsaikhan, Fahad
AU - Margiana, Ria
AU - Ahmad, Irfan
AU - Patra, Indrajit
AU - Najm, Mazin A.A.
AU - Yasin, Ghulam
AU - Rasulova, Iroda
AU - Hammid, Ali Thaeer
AU - Kzar, Hamzah H.
AU - Al-Gazally, Moaed E.
AU - Siahmansouri, Homayoon
N1 - Funding Information:
This work was financially supported by Scientific Research Deanship at King Khalid University, Abha, Saudi Arabia, through the Large Research Group Project under grant number (RGP.02-87-43). The funding bodies played no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.
Funding Information:
The authors are grateful to Scientific Research Deanship at King Khalid University, Abha, Saudi Arabia for their financial support through the Large Research Group Project under grant number (RGP.02-87-43).
Publisher Copyright:
© 2023, The Author(s).
PY - 2023/12
Y1 - 2023/12
N2 - In women, breast cancer (BC) is the second most frequently diagnosed cancer and the leading cause of cancer death. Mesenchymal stem cells (MSCs) are a subgroup of heterogeneous non-hematopoietic fibroblast-like cells that have the ability to differentiate into multiple cell types. Recent studies stated that MSCs can migrate into the tumor sites and exert various effect on tumor growth and development. Multiple researches have demonstrated that MSCs can favor tumor growth, while other groups have indicated that MSCs inhibit tumor development. Emerging evidences showed exosomes (Exo) as a new mechanism of cell communication which are essential for the crosstalk between MSCs and BC cells. MSC-derived Exo (MSCs-Exo) could mimic the numerous effects on the proliferation, metastasis, and drug response through carrying a wide scale of molecules, such as proteins, lipids, messenger RNAs, and microRNAs to BC cells. Consequently, in the present literature, we summarized the biogenesis and cargo of Exo and reviewed the role of MSCs-Exo in development of BC.
AB - In women, breast cancer (BC) is the second most frequently diagnosed cancer and the leading cause of cancer death. Mesenchymal stem cells (MSCs) are a subgroup of heterogeneous non-hematopoietic fibroblast-like cells that have the ability to differentiate into multiple cell types. Recent studies stated that MSCs can migrate into the tumor sites and exert various effect on tumor growth and development. Multiple researches have demonstrated that MSCs can favor tumor growth, while other groups have indicated that MSCs inhibit tumor development. Emerging evidences showed exosomes (Exo) as a new mechanism of cell communication which are essential for the crosstalk between MSCs and BC cells. MSC-derived Exo (MSCs-Exo) could mimic the numerous effects on the proliferation, metastasis, and drug response through carrying a wide scale of molecules, such as proteins, lipids, messenger RNAs, and microRNAs to BC cells. Consequently, in the present literature, we summarized the biogenesis and cargo of Exo and reviewed the role of MSCs-Exo in development of BC.
KW - Breast cancer
KW - Exosome
KW - Extracellular vesicles
KW - Mesenchymal stem cell
KW - Tumor
UR - http://www.scopus.com/inward/record.url?scp=85147637604&partnerID=8YFLogxK
U2 - 10.1186/s13287-023-03245-3
DO - 10.1186/s13287-023-03245-3
M3 - Review article
C2 - 36750912
AN - SCOPUS:85147637604
SN - 1757-6512
VL - 14
JO - Stem Cell Research and Therapy
JF - Stem Cell Research and Therapy
IS - 1
M1 - 21
ER -
